Necrosulfonamide Promotes Hair Growth and Ameliorates DHT-Induced Hair Growth Inhibition

    April 2024 in “ Journal of Dermatological Science ”
    Yuanhong Liu, Shengbo Yang, Lina Tan … Dan Wang
    Studysummary This study suggests that the MLKL-targeting inhibitor Necrosulfonamide promotes hair growth and counteracts DHT inhibition by activating Wnt signaling in hair follicle cells, revealing potential avenues for anti-alopecia drug development.
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    Research cited in this study 13

    1. Dissolving Microneedles for Alopecia Treatment Colloids and surfaces. B, Biointerfaces · 2023
    2. Adipose Mesenchymal Stromal Cell-Derived Exosomes Carrying MiR-122-5p Antagonize the Inhibitory Effect of Dihydrotestosterone on Hair Follicles by Targeting the TGF-β1/SMAD3 Signaling Pathway International Journal of Molecular Sciences · 2023
    3. Reducing Surgical Risks For Hair Replacement Surgery Facial Plastic Surgery Clinics of North America · 2023
    4. ROR2 Regulates Self-Renewal and Maintenance of Hair Follicle Stem Cells Nature Communications · 2022
    5. A Systematic Summary of Survival and Death Signaling During the Life of Hair Follicle Stem Cells Stem Cell Research & Therapy · 2021
    6. Androgens Downregulate BMP2, Impairing the Inductive Role of Dermal Papilla Cells on Hair Follicle Stem Cells Differentiation Molecular and Cellular Endocrinology · 2020
    7. Formulation of Sodium Valproate Nanospanlastics as a Promising Approach for Drug Repurposing in the Treatment of Androgenic Alopecia Pharmaceutics · 2020
    8. Dihydrotestosterone Regulates Hair Growth Through the Wnt/β-Catenin Pathway in C57BL/6 Mice and In Vitro Organ Culture Frontiers in Pharmacology · 2020
    9. Wnt/β-Catenin Signaling Promotes Aging-Associated Hair Graying in Mice Oncotarget · 2017
    10. Signaling Involved in Hair Follicle Morphogenesis and Development International Journal of Molecular Sciences · 2014
    11. Keratinocyte Growth Inhibition Through the Modification of Wnt Signaling by Androgen in Balding Dermal Papilla Cells ˜The œJournal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 2009
    12. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007
    13. Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla Journal of Investigative Dermatology · 2003

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