Necrosulfonamide Promotes Hair Growth and Ameliorates DHT-Induced Hair Growth Inhibition

April 2024 in “ Journal of Dermatological Science ”

Yuanhong Liu, Shengbo Yang, Lina Tan, Xuemei Li, Daijing Long, Jianyun Lu, Dan Wang

Necrosulfonamide MLKL dihydrotestosterone androgenetic alopecia outer root sheath Wnt signaling dermal papillae cells NSA DHT AGA ORS DPCs

Studysummary This study suggests that the MLKL-targeting inhibitor Necrosulfonamide promotes hair growth and counteracts DHT inhibition by activating Wnt signaling in hair follicle cells, revealing potential avenues for anti-alopecia drug development. Our plain-language summary of this paper — not a Tressless recommendation.

The study investigates the role of Mixed-lineage kinase domain-like pseudokinase (MLKL) in hair growth, particularly in androgenetic alopecia (AGA) patients, and the potential of Necrosulfonamide (NSA) as a treatment. It was found that MLKL expression is elevated in alopecia areas of AGA patients and in the outer root sheath (ORS) cells of mice hair follicles. Knockdown of MLKL or inhibition by NSA promoted hair growth and counteracted dihydrotestosterone (DHT)-induced hair growth inhibition. NSA enhances hair growth by inhibiting MLKL activation, promoting Wnt signaling in dermal papillae cells (DPCs), and fostering ORS cell proliferation. This suggests NSA could be a promising anti-alopecia treatment by targeting MLKL-mediated pathways.

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Research cited in this study

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