Formulation of Sodium Valproate Nanospanlastics as a Promising Approach for Drug Repurposing in the Treatment of Androgenic Alopecia

    September 2020 in “ Pharmaceutics ”
    Farid A. Badria, Hassan E. Fayed, Amira Mofreh Ibraheem … Eman A. Mazyed
    Studysummary This study investigated a new formula called SV-loaded nanospanlastics for topical application to treat androgenic alopecia. It showed similar effectiveness to minoxidil lotion but with fewer adverse effects when used to enhance dermal delivery and efficacy of sodium valproate.
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    Research cited in this study 19

    1. Comparative Study Between Mesotherapy and Topical 5% Minoxidil by Dermoscopic Evaluation for Androgenic Alopecia in Males: A Randomized Controlled Trial International Journal of Trichology · 2019
    2. Oleic Acid Nanovesicles of Minoxidil for Enhanced Follicular Delivery Medicines · 2018
    3. Finasteride Nano-Transferosomal Gel Formula for Management of Androgenetic Alopecia: Ex Vivo Investigational Approach Drug Design Development and Therapy · 2018
    4. Formulation and Optimization of Transfersome Containing Minoxidil and Caffeine Journal of Drug Delivery Science and Technology · 2017
    5. Transdermal Permeation of Drugs in Various Animal Species Pharmaceutics · 2017
    6. Comparative Study of Efficacy of Topical Minoxidil 5% and Combination of Topical Minoxidil 5%, Topical Azelaic Acid 1.5% and Topical Tretinoin 0.01% Based on Dermoscopic Analysis in Androgenetic Alopecia MVP journal of medical science · 2015
    7. Topical Minoxidil Fortified with Finasteride: Maintenance of Hair Density After Replacing Oral Finasteride Indian Dermatology Online Journal · 2015
    8. Topical Valproic Acid Increases Hair Count in Male Patients with Androgenetic Alopecia: A Randomized, Comparative, Clinical Feasibility Study Using Phototrichogram Analysis Journal of Dermatology · 2014
    9. Niosomes as a Vesicular Carrier for Topical Administration of Minoxidil: Formulation and In Vitro Assessment Drug Delivery and Translational Research · 2013
    10. Female Pattern Alopecia: Current Perspectives International Journal of Women's Health · 2013
    11. A Case of Androgenetic Alopecia Treated with Valproic Acid International Journal of Dermatology · 2013
    12. Application of the Basic and Specific Classification on Patterned Hair Loss in Indians International Journal of Trichology · 2013
    13. Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells PLOS ONE · 2012
    14. Male Androgenetic Alopecia Expert Opinion on Pharmacotherapy · 2010
    15. The Role of Scalp Dermoscopy in the Diagnosis of Alopecia Areata Incognita Journal of The American Academy of Dermatology · 2008
    16. Possible Mechanisms of Miniaturization During Androgenetic Alopecia or Pattern Hair Loss Journal of The American Academy of Dermatology · 2001
    17. Changes in Hair Weight and Hair Count in Men with Androgenetic Alopecia After Application of 5% and 2% Topical Minoxidil, Placebo, or No Treatment Journal of The American Academy of Dermatology · 1999
    18. Tolerance to and Unwanted Effects of Valproate Sodium PubMed · 1994
    19. Classification of the Types of Androgenetic Alopecia (Common Baldness) Occurring in the Female Sex British Journal of Dermatology · 1977

    Related research 7

    1. Topical Effect of Minoxidil Containing Lotion on Morphofunctional Indicators of Male Rats’ Reproductive System Ukraïnsʹkij žurnal sučasnih problem toksikologìï · 2020
    2. Platelet-Rich Plasma and Microneedling Improve Hair Growth in Patients with Androgenetic Alopecia When Used as an Adjuvant to Minoxidil Journal of Cosmetic Dermatology · 2019
    3. A Comparative Study Between the Efficacy and Safety of 5% Minoxidil Solution and 5% Minoxidil Milky Lotion in the Treatment of Male Androgenic Alopecia PubMed · 2017
    4. Comparative Study of Efficacy of Topical Minoxidil 5% and Combination of Topical Minoxidil 5%, Topical Azelaic Acid 1.5% and Topical Tretinoin 0.01% Based on Dermoscopic Analysis in Androgenetic Alopecia MVP journal of medical science · 2015
    5. Kerion Celsi Favored by the Use of a Tretinoin, Minoxidil, and Betamethasone Valerate Lotion in a 28-Year-Old Woman PubMed · 2010
    6. Topical Minoxidil Useful in 18% of Patients with Androgenetic Alopecia: A Study of 430 Cases Dermatology · 1986
    7. Topical Minoxidil for Extended Alopecia Areata Acta Dermato Venereologica · 1985