Formulation of Sodium Valproate Nanospanlastics as a Promising Approach for Drug Repurposing in the Treatment of Androgenic Alopecia

September 2020 in “ Pharmaceutics ”

Farid A. Badria, Hassan E. Fayed, Amira Mofreh Ibraheem, Ahmed F. State, Eman A. Mazyed

Sodium Valproate nanospanlastics androgenic alopecia minoxidil topical delivery ex vivo permeation SV AGA Rogaine

TLDR Sodium Valproate nanospanlastics could be a safe and effective treatment for Androgenic Alopecia, with fewer side effects than minoxidil.

In 2020, a study was conducted to investigate the potential of Sodium Valproate (SV) nanospanlastics for the treatment of Androgenic Alopecia (AGA). The study involved the formulation and optimization of SV-loaded nanospanlastics, which were then characterized using various techniques. The optimized formula (F8) showed a significant improvement in ex vivo permeation compared to free SV. A clinical trial was conducted with 80 patients, divided into two groups. Group A was treated with the optimized SV-loaded nanospanlastic dispersion, while Group B was treated with a marketed 5% minoxidil lotion. The results showed that SV-loaded nanospanlastics were as effective as minoxidil in treating AGA, with fewer side effects. The study concluded that nanospanlastics could be a safe and effective method for improving the topical delivery of SV in the management of AGA.

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18 / 18 results

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6 / 6 results

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January 2017 in “PubMed”

Both 5% minoxidil solution and milky lotion effectively and safely treat male hair loss, with the lotion being a good alternative for those sensitive to certain ingredients.

research Comparative Study of Efficacy of Topical Minoxidil 5% and Combination of Topical Minoxidil 5%, Topical Azelaic Acid 1.5% and Topical Tretinoin 0.01% Based on Dermoscopic Analysis in Androgenetic Alopecia

1 citations , December 2015 in “MVP journal of medical science”

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16 citations , July 1986 in “Dermatology”

Using minoxidil lotion for hair regrowth in androgenetic alopecia has limited success and should be evaluated carefully.