Topical Effect of Minoxidil Containing Lotion on Morphofunctional Indicators of Male Rats’ Reproductive System

    November 2020 in “ Ukraïnsʹkij žurnal sučasnih problem toksikologìï ”
    V. А. Turkina, N.Ye. Chemodurova, Oksana Grushka, H.V. Pryzyhlei
    Image of study
    TLDR Minoxidil lotion may harm male reproductive health.
    In 2020, Danylo Halytsky Lviv National Medical University in Ukraine conducted a study on 20 male rats to investigate the effects of a 10% minoxidil containing lotion on their reproductive system. The rats were divided into two groups, with one group exposed to the lotion for 72 days. The results showed a significant decrease in the mass and size of the testes and epididymis, a shortened total time of motor activity of spermatozoa, and a 6-fold inhibition of redox processes in the experimental group compared to the control group. The study concluded that long-term and uncontrolled use of 10% minoxidil lotions could potentially have gonadotoxic effects on men of reproductive age, suggesting the need for further in-depth study.
    Discuss this study in the Community →

    Research cited in this study

    5 / 5 results

    Related Community Posts Join

    6 / 1000+ results

      community Quit vaping/smoking = 80% less loss

      in Research/Science  235 upvotes 1 year ago
      Quitting vaping significantly reduced hair loss for a user who was a heavy vaper and also taking finasteride. Some participants suggest nicotine's vasoconstrictive properties may worsen hair loss, while others share personal anecdotes of hair improvement after quitting smoking or vaping.

      community DHT Isn't (Directly) Important

      in Research/Science  100 upvotes 1 year ago
      Finasteride's potential side effects, especially sexual dysfunction, are discussed, with emphasis on hormonal balance between testosterone and estradiol. Users share experiences with finasteride, minoxidil, and dutasteride, highlighting the variability in side effects and the influence of mindset and lifestyle.

      community Creatine is the opposite of minoxidil !

      in Research/Science  321 upvotes 4 months ago
      Creatine may counteract minoxidil's hair growth effects by closing potassium ATP channels, potentially leading to hair loss in predisposed individuals. Despite anecdotal reports, there is no conclusive evidence linking creatine to hair loss.

      community Why is Kevin Mann (Haircafe) Hated?

      in Chat  62 upvotes 2 years ago
      Hair loss treatments, including microneedling, minoxidil, finasteride and RU58841; the efficacy of these treatments; criticisms of Kevin Mann's content related to his selective data presentation and biases towards certain treatments; and other topics such as DHT being labeled a "trash hormone" and critiques of other hairloss YouTubers.

    Related Research

    2 / 2 results