Comparative Study of Efficacy of Topical Minoxidil 5% and Combination of Topical Minoxidil 5%, Topical Azelaic Acid 1.5% and Topical Tretinoin 0.01% Based on Dermoscopic Analysis in Androgenetic Alopecia

September 2015 in “ MVP journal of medical science ”

Anil Gugle, Vikrant V. Jadhav, Rahul Kote, Milind M. Deshmukh, Aditi A. Dalvi

minoxidil azelaic acid tretinoin androgenetic alopecia dermoscopic analysis Rogaine

From the encyclopedia

Minoxidil →

An essential vasodilator with some anti-androgenic effects

Azelaic Acid →

acid used for antimicrobial, anti-inflammatory and anti-androgenic properties

Tretinoin →

the gold standard retinoid in dermatology that's also helpful for hair regrowth alongside Minoxidil

Studysummary In this study, the combination of minoxidil, azelaic acid, and tretinoin showed no significant advantage over minoxidil alone for treating androgenetic alopecia. Our plain-language summary of this paper — not a Tressless recommendation.

The study compared the efficacy of topical Minoxidil 5% alone versus a combination of topical Minoxidil 5%, Azelaic Acid 1.5%, and Tretinoin 0.01% in treating androgenetic alopecia. Conducted in a dermatology outpatient department, the study involved 46 patients, with 23 patients in each treatment group. Results showed a statistically significant increase in hair number and thickness in both groups, but no significant difference between the two treatments. The conclusion was that topical Minoxidil 5% was as effective as the combination treatment for androgenetic alopecia.

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