Comorbidities in Patients with Lichen Planopilaris: A Retrospective Case-Control Study
July 2020
in “
Journal of The American Academy of Dermatology
”
TLDR Patients with Lichen Planopilaris are more likely to have rosacea and skin cancer but less likely to have congestive heart failure, stroke, and glaucoma.
In a retrospective case-control study with 232 patients with Lichen Planopilaris (LPP) or Frontal Fibrosing Alopecia (FFA) and 194 controls, it was found that LPP patients had significantly higher odds of having rosacea (OR 4.43) and skin cancer (OR 5.67), but no significant difference in overall cardiovascular disease compared to controls. However, LPP patients had lower odds of congestive heart failure (OR 0.28) and stroke (OR 0.23), as well as significantly lower odds of glaucoma (OR 0.034). The association between LPP and alopecia areata was not statistically significant (OR 12.94). The findings indicate a need for further research on the link between dermatologic conditions and LPP and suggest considering increased skin cancer surveillance for LPP patients. The study's retrospective design may have introduced selection bias.
