Comorbidities In Patients With Central Centrifugal Cicatricial Alopecia: A Case-Control Study

    November 2023 in “ International Journal of Dermatology ”
    Tejas P. Joshi, Anthony Duruewuru, Danielle Garcia, Nabor Stephen Mireles, Paulina Truong, Clay J. Cockerell
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    TLDR Patients with central centrifugal cicatricial alopecia often have higher rates of metabolic, autoimmune, and atopic conditions, as well as anxiety and depression.
    This study investigates comorbidities in patients with central centrifugal cicatricial alopecia (CCCA) using data from the National Institute of Health's All of Us research program. The nested case-control study included 201 CCCA patients and matched controls. Findings revealed that CCCA patients had significantly higher odds of metabolic abnormalities such as hyperlipidemia (OR: 5.20), hypertension (OR: 8.62), and type 2 diabetes (OR: 5.66). They also had increased odds of autoimmune conditions (OR: 4.92) and atopic conditions like allergic rhinitis (OR: 6.03), asthma (OR: 3.55), and atopic dermatitis (OR: 4.94). Additionally, CCCA patients showed a higher prevalence of anxiety and depression. The study suggests that shared inflammatory pathways may mediate CCCA and its comorbidities, and highlights the potential role of Th2 inflammation. The findings underscore the importance of comprehensive care for CCCA patients, including screening for these comorbidities.
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