Hair Regrowth in a Patient With Central Centrifugal Cicatricial Alopecia After a 2-Month Trial of Baricitinib

July 2023 in “ JAAD Case Reports ”

Kathryn Workman, Chesahna Kindred

central centrifugal cicatricial alopecia CCCA baricitinib Janus Kinase inhibitor JAK inhibitor doxycycline oral minoxidil topical halcinonide triamcinolone injections inflammation hair regrowth

TLDR A woman with a type of hair loss saw hair regrowth after two months of taking baricitinib.

A 42-year-old African-American woman with a 5-year history of central centrifugal cicatricial alopecia (CCCA), a type of hair loss common in African-American women, showed significant hair regrowth after a two-month trial of baricitinib, a Janus Kinase (JAK) inhibitor. The patient had previously been treated with various medications, including oral doxycycline, oral minoxidil, topical halcinonide, and monthly triamcinolone injections, but her condition repeatedly worsened when the injections were extended beyond once a month. After two years, inflammation symptoms returned despite treatment adherence. The patient was then put on a trial of baricitinib, and after one month, her symptoms resolved. After two months, hair regrowth was noted in the area of her scalp affected by CCCA. This case suggests that JAK inhibitors like baricitinib could potentially be effective treatment options for CCCA, although further research is needed to understand their role in the disease's pathogenesis.

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Research cited in this study

4 / 4 results

research Two Phase 3 Trials of Baricitinib for Alopecia Areata

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Baricitinib was effective in treating alopecia areata in two major trials.

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Mutations in the PADI3 gene are linked to a higher risk of scarring hair loss in women of African descent.

research Central Centrifugal Cicatricial Alopecia: Past, Present, and Future

75 citations, March 2009 in “Journal of The American Academy of Dermatology”

CCCA is a hair loss type affecting African women, possibly caused by grooming and chemicals, with various treatments and needing more research.

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community I am a dermatologist with a clinical interest in alopecia. AMA

in Will treatment work for me? 2 years ago

In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 4 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community lost my hair in a single year of treatment at 20 years old

in Finasteride/Dutasteride 89 upvotes 4 months ago

A 20-year-old lost significant hair after one year of treatment, using minoxidil, finasteride, and later dutasteride. They are considering adding RU58841 but are advised to return to finasteride and minoxidil for a year before deciding.

community Wanted to say that Derma rolling and Pumpkin seed oil helped my crown out.

in Treatment 4 upvotes 5 years ago

Derma rolling, pumpkin seed oil, and daily massages helped regrow weak hairs on the crown. Nizoral shampoo and yoga also contributed to reducing scalp pain and stress.

community Finasteride doesn't work for me in 2 years and my bloodtest result just came in.

in Progress Pictures 88 upvotes 1 year ago

A user has been treating hair loss with finasteride for two years without success and is experiencing an itchy scalp with seborrhea. Despite low DHT levels, they are still losing hair, suggesting that DHT might not be the main cause of their hair loss, and they are considering other treatments or causes.

community Exploring Bryan Johnson's Hair Routine In Detail

in Research/Science 64 upvotes 11 months ago

Bryan Johnson uses a custom hair loss treatment that includes topical finasteride, minoxidil, azelaic acid, diclofenac, tea tree oil, rosemary oil, ginkgo biloba, biotin, and melatonin, which have shown varying degrees of effectiveness with minimal side effects. He also undergoes PRP and laser therapy, and has tried dutasteride mesotherapy.

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