Beyond The Hot Comb: Updates In Epidemiology, Pathogenesis, And Treatment Of Central Centrifugal Cicatricial Alopecia From 2011 To 2021

November 2022 in “ American Journal of Clinical Dermatology ”

Elisabeth A. George, Caneisaya Matthews, Fritzlaine C. Roche, Susan C. Taylor

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$Treatment-Refractory Central Centrifugal Cicatricial Alopecia Responsive to a Novel Botanical Treatment$

research Treatment-Refractory Central Centrifugal Cicatricial Alopecia Responsive to a Novel Botanical Treatment

2 citations , April 2022 in “Clinical, cosmetic and investigational dermatology”

In this case series, four African American women with treatment-resistant central centrifugal cicatricial alopecia showed scalp itch relief and significant hair regrowth after using a new botanical formula for 8 weeks to 1 year, with no adverse effects reported.

Clinical and Dermoscopic Approaches to Diagnosis of Frontal Fibrosing Alopecia: Results From a Multicenter Study of the International Dermoscopy Society

research Clinical and Dermoscopic Approaches to Diagnosis of Frontal Fibrosing Alopecia: Results From a Multicenter Study of the International Dermoscopy Society

3 citations , February 2022 in “Dermatology practical & conceptual”

This study found that trichoscopy is an effective noninvasive technique for diagnosing frontal fibrosing alopecia, confirming its valuable role alongside traditional histopathological examination.

research Topical Treatment for Scarring and Non-Scarring Alopecia: An Overview of the Current Evidence

19 citations , May 2021 in “Clinical, Cosmetic and Investigational Dermatology”

This review discusses the progress in research on topical formulations for treating alopecia, highlighting potential advantages of advanced formulation technologies but reporting no new clinical results.

research Association of Breast and Colorectal Cancer in Patients With Central Centrifugal Cicatricial Alopecia: A Retrospective, Cross-Sectional Pilot Study

9 citations , October 2020 in “Journal of the American Academy of Dermatology”

Patients with central centrifugal cicatricial alopecia may have a higher risk of breast and colorectal cancer.

The Use of Natural Ingredients in the Treatment of Alopecias with an Emphasis on Central Centrifugal Cicatricial Alopecia: A Systematic Review

research The Use of Natural Ingredients in the Treatment of Alopecias with an Emphasis on Central Centrifugal Cicatricial Alopecia: A Systematic Review

3 citations , August 2020 in “PubMed”

This review discusses the absence of clinical trials on natural ingredients for managing Central Centrifugal Cicatricial Alopecia and highlights a need for more research.

research Dermatoscopic Evaluation of Central Centrifugal Cicatricial Alopecia Beyond the Vertex Scalp

9 citations , July 2020 in “JAMA dermatology”

This study explored dermatoscopic and histopathologic findings of central centrifugal cicatricial alopecia beyond the vertex scalp, suggesting that dermatoscopy might serve as a less invasive diagnostic tool for subclinical disease.

research Platelet-Rich Plasma and Its Use for Cicatricial and Non-Cicatricial Alopecias: A Narrative Review

12 citations , June 2020 in “Dermatology and therapy”

This article reviews major uses of platelet-rich plasma in treating various hair disorders, including both non-cicatricial and cicatricial alopecia, but reports no new results.

research Hair Regrowth in Two Patients with Recalcitrant Central Centrifugal Cicatricial Alopecia After Use of Topical Metformin

24 citations , January 2020 in “JAAD Case Reports”

This article discusses the staging of central centrifugal cicatricial alopecia in women of African descent and reports no new clinical results.

research Fibrosing Alopecia in a Pattern Distribution

30 citations , January 2020 in “Journal of The American Academy of Dermatology”

This review reports no new clinical results but discusses fibrosing alopecia in a pattern distribution as a distinct scarring alopecia with characteristics of both androgenetic alopecia and lichen planopilaris.

research Association of Type 2 Diabetes With Central-Scalp Hair Loss in a Large Cohort Study of African American Women

16 citations , June 2019 in “International Journal of Women's Dermatology”

This study found that type 2 diabetes was associated with a higher risk of severe central scalp hair loss in African American women.

research Variant PADI3 in Central Centrifugal Cicatricial Alopecia

95 citations , February 2019 in “The New England Journal of Medicine”

This article discusses the potential genetic basis of central centrifugal cicatricial alopecia in women of African ancestry but does not provide new research results.

research Current and Emerging Treatment Strategies for Hair Loss in Women of Color

15 citations , January 2019 in “International Journal of Women's Dermatology”

This review discusses clinical presentations and interventions for alopecia in women of color, highlighting the importance of early recognition and treatment but providing no new clinical results.

research Frequency of the Types of Alopecia at Twenty-Two Specialist Hair Clinics: A Multicenter Study

56 citations , January 2019 in “Skin appendage disorders”

In this multicenter study, androgenetic alopecia was the most common type of alopecia among both men and women attending specialty hair clinics on four continents.

research A Systematic Review of the Outcome of Hair Transplantation in Primary Scarring Alopecia

27 citations , September 2018 in “Skin appendage disorders”

This review suggests that hair transplantation may be a viable treatment option for certain primary scarring alopecias, although findings should be interpreted cautiously due to possible publication bias favoring positive results.

research Use of Platelet-Rich Plasma in Cicatricial Alopecia

28 citations , August 2018 in “Dermatologic Surgery”

This abstract is a listing of affiliations and funding, with no new study or results reported.

research Fibroproliferative Genes Are Preferentially Expressed in Central Centrifugal Cicatricial Alopecia

25 citations , June 2018 in “Journal of The American Academy of Dermatology”

This study identified upregulation of genes linked to fibroproliferative disorders, such as platelet-derived growth factor and collagen genes, in patients with central centrifugal cicatricial alopecia, suggesting potential therapeutic targets.

research Fibroproliferative Genes Are Preferentially Expressed in Central Centrifugal Cicatricial Alopecia

3 citations , April 2018 in “Journal of Investigative Dermatology”

CCCA may be a fibroproliferative disorder, and anti-fibrotic therapies could help.

research Central Centrifugal Cicatricial Alopecia: New Insights and a Call for Action

27 citations , September 2017 in “Journal of Investigative Dermatology Symposium Proceedings”

This article discusses central centrifugal cicatricial alopecia, noting its prevalence in women of African descent and highlighting the need for further genetic research to improve treatment options; it reports no new clinical results.

research Updates in the Understanding and Treatments of Skin and Hair Disorders in Women of Color

61 citations , February 2017 in “International Journal of Women’s Dermatology”

This review discusses skin disorders in women of color, highlighting unique presentations like dyschromias from acne, and underscores the need for more research on racial and ethnic differences; it reports no new clinical results.

research Primary Cicatricial Alopecia

65 citations , November 2016 in “Journal of The American Academy of Dermatology”

This article reviews various types of primary cicatricial alopecias and emphasizes the importance of accurate diagnosis to improve management strategies, particularly detailing remaining lymphocytic forms and expanding on neutrophilic and mixed types.

research Central Centrifugal Cicatricial Alopecia: Challenges and Solutions

37 citations , August 2016 in “Clinical, Cosmetic and Investigational Dermatology”

This article discusses central centrifugal cicatricial alopecia, highlighting its prevalence, potential genetic factors, and management challenges, but reports no new clinical conclusions and calls for further research.

research Factors Affecting the Severity of Central Centrifugal Cicatricial Alopecia

29 citations , January 2016 in “International Journal of Dermatology”

This study reports that the duration of hair loss is positively associated with the severity of central centrifugal cicatricial alopecia in African-American women.

research Black Women's Hair: The Main Scalp Dermatoses and Aesthetic Practices in Women of African Ethnicity

32 citations , August 2015 in “Anais Brasileiros de Dermatologia”

This review discusses the side effects and diseases related to hairstyles and hair treatments among black women, highlighting the need for thorough examination by dermatologists, but reports no new clinical results.

research Female Pattern Hair Loss: A Clinical and Pathophysiological Review

91 citations , August 2015 in “Anais Brasileiros De Dermatologia”

This review discusses the clinical, epidemiological, and pathophysiological aspects of female pattern hair loss, reporting no new research findings.

research Pathologic Diagnosis of Central Centrifugal Cicatricial Alopecia on Horizontal Sections

29 citations , September 2014 in “American Journal of Dermatopathology”

This study found that horizontal sections of scalp biopsies in patients with Central Centrifugal Cicatricial Alopecia often reveal follicular miniaturization, inflammation, and scarring, which can guide personalized treatment.

research Hair Transplantation in the Surgical Treatment of Central Centrifugal Cicatricial Alopecia

25 citations , September 2014 in “Dermatologic Surgery”

This study found that hair transplantation using round grafts improved hair growth in African American women with end-stage CCCA, showing no postoperative scarring in the donor or recipient areas.

research Dermatoscopic Features of Central Centrifugal Cicatricial Alopecia

64 citations , June 2014 in “Journal of The American Academy of Dermatology”

This study found that a peripilar white gray halo around hair emergence is a highly specific and sensitive dermatoscopic feature for diagnosing central centrifugal cicatricial alopecia in African American patients with mild central thinning.

research Elastin Staining Patterns in Primary Cicatricial Alopecia

30 citations , November 2013 in “Journal of The American Academy of Dermatology”

This study reported that patterns of fibrosis identified through elastin staining may help distinguish specific forms of primary cicatricial alopecia in biopsy specimens, with certain patterns suggesting particular diagnoses.

research Hair and Scalp Disorders in Women of African Descent: An Overview

20 citations , October 2013 in “British Journal of Dermatology”

The document concludes that clinicians should be aware of common hair and scalp disorders in women of African descent and that more research is needed to develop effective treatments.

research Lichen Planopilaris Is Characterized By Immune Privilege Collapse Of The Hair Follicle's Epithelial Stem Cell Niche

220 citations , June 2013 in “The Journal of Pathology”

This study found that immune privilege collapse in the hair follicle bulge and associated immune responses may contribute significantly to the pathogenesis of lichen planopilaris, suggesting a potential autoimmune basis for the disease.

research Primary Cicatricial Alopecia: Diagnosis and Treatment

48 citations , May 2013 in “Canadian Medical Association Journal”

This article discusses common causes of hair loss, specifically androgenetic alopecia and alopecia areata, but reports no new clinical findings.

research Central Centrifugal Cicatricial Alopecia: Possible Familial Aetiology in Two African Families from South Africa

15 citations , November 2012 in “International Journal of Dermatology”

This case series observed a potential familial link in central centrifugal cicatricial alopecia (CCCA), suggesting a genetic predisposition that may be worsened by hair grooming practices.

research Primary Cicatricial Alopecias

18 citations , October 2012 in “Dermatologic Clinics”

This article discusses primary cicatricial alopecias, a group of rare inflammatory scalp disorders resulting in permanent hair loss, and reports no new findings.

research Hair Breakage as a Presenting Sign of Early or Occult Central Centrifugal Cicatricial Alopecia

44 citations , September 2012 in “Archives of Dermatology”

This study observed that hair breakage may indicate early central centrifugal cicatricial alopecia in African American women, suggesting that it should be considered in their differential diagnosis.

research Central Centrifugal Cicatricial Alopecia: An Approach to Diagnosis and Management

32 citations , November 2011 in “International Journal of Dermatology”

This article reviews central centrifugal cicatricial alopecia, focusing on its multifactorial etiology and challenges in clinical diagnosis, and calls for more research and better treatment options.

research Medical and Environmental Risk Factors for the Development of Central Centrifugal Cicatricial Alopecia

88 citations , April 2011 in “Archives of Dermatology”

This study found a high prevalence of central hair loss among African American women and associated it with diabetes mellitus type 2, bacterial scalp infections, and hairstyles causing traction.

research Central Hair Loss in African American Women: Incidence and Potential Risk Factors

76 citations , November 2010 in “Journal of The American Academy of Dermatology”

In this study, a photographic scale and questionnaire revealed that extensive central scalp hair loss was observed in 5.6% of African American women, with an association to a history of tinea capitis.

research Central Centrifugal Cicatricial Alopecia: Retrospective Chart Review

25 citations , September 2010 in “Journal of Cutaneous Medicine and Surgery”

This study found that central centrifugal cicatricial alopecia primarily affects adult women of African descent and suggests an association with traumatic hair care practices and delayed diagnosis.

research A New Approach to Treating Scarring Alopecia by Hair Transplantation and Topical Minoxidil

11 citations , January 2010 in “Indian Journal of Dermatology, Venereology and Leprology”

Hair transplant and applying 5% minoxidil solution can effectively treat permanent hair loss, but it may change hair direction in some cases.

research Central Centrifugal Cicatricial Alopecia

72 citations , July 2008 in “Dermatologic Therapy”

This article reviews central centrifugal cicatricial alopecia in African-descent females, discussing possible causes, associated styling habits, and potential treatments, but reports no new clinical findings; the authors call for further research.

research Medical and Surgical Therapies for Alopecias in Black Women

105 citations , April 2004 in “Dermatologic Therapy”

This review discusses medical and surgical therapies for alopecias in Black women, focusing on the impact of hair-care practices and the importance of patient education, but reports no new clinical results.

research Hair Density in African Americans

129 citations , June 1999 in “Archives of Dermatology”

This study found that hair density is significantly lower in African Americans compared to whites, which may affect the evaluation and diagnosis of scalp biopsy specimens in this population.