Pathologic Diagnosis of Central Centrifugal Cicatricial Alopecia on Horizontal Sections

September 2014 in “ American Journal of Dermatopathology ”

Mariya Miteva, Antonella Tosti

Central Centrifugal Cicatricial Alopecia CCCA follicular miniaturization inner root sheath desquamation sebaceous glands compound follicular structures perifollicular fibrosis perifollicular inflammation lamellar hyperkeratosis parakeratosis naked hair shafts goggles sign hair follicle shrinkage hair follicle structures fibrosis around hair follicles inflammation around hair follicles thickened skin layers skin cell retention exposed hair shafts

Studysummary This study found that horizontal sections of scalp biopsies in patients with Central Centrifugal Cicatricial Alopecia often reveal follicular miniaturization, inflammation, and scarring, which can guide personalized treatment.

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research A Comprehensive Approach to Hair Pathology of Horizontal Sections

12 citations , June 2013 in “The American Journal of Dermatopathology”

This study reported that using photomnemonics facilitated accurate histopathologic interpretation of horizontal scalp sections in distinguishing between nonscarring and scarring alopecias by dermatopathologists and residents in a validation test.

research Follicular Density and Ratios in Scarring and Nonscarring Alopecia

19 citations , February 2013 in “The American Journal of Dermatopathology”

This study found that follicular density and various hair growth ratios differ statistically between nonscarring and scarring alopecia, though significant overlap exists due to factors like sample size and scalp variation.

research Hair Breakage as a Presenting Sign of Early or Occult Central Centrifugal Cicatricial Alopecia

44 citations , September 2012 in “Archives of Dermatology”

This study observed that hair breakage may indicate early central centrifugal cicatricial alopecia in African American women, suggesting that it should be considered in their differential diagnosis.

research A Detective Look at Hair Biopsies from African-American Patients

40 citations , May 2012 in “British Journal of Dermatology”

This study reviewed scalp biopsies from African-American patients, identifying distinct features and diagnostic clues for scarring alopecia types such as traction alopecia and central centrifugal cicatricial alopecia.

research Prevalence and Etiology of Central Centrifugal Cicatricial Alopecia

19 citations , August 2011 in “Archives of Dermatology”

This abstract contains no research findings but is a snippet of a website interface for JAMA Dermatology.

research Sebaceous Gland Loss and Inflammation in Scarring Alopecia: A Potential Role in Pathogenesis

37 citations , June 2011 in “Journal of The American Academy of Dermatology”

This study demonstrates that sebaceous gland loss is a common early feature in primary scarring alopecia and suggests that inflammation of sebaceous glands or ducts may contribute to follicular damage.

research Medical and Environmental Risk Factors for the Development of Central Centrifugal Cicatricial Alopecia

88 citations , April 2011 in “Archives of Dermatology”

This study found a high prevalence of central hair loss among African American women and associated it with diabetes mellitus type 2, bacterial scalp infections, and hairstyles causing traction.

research Central Hair Loss in African American Women: Incidence and Potential Risk Factors

76 citations , November 2010 in “Journal of The American Academy of Dermatology”

In this study, a photographic scale and questionnaire revealed that extensive central scalp hair loss was observed in 5.6% of African American women, with an association to a history of tinea capitis.

research Central Scalp Alopecia Photographic Scale in African American Women

46 citations , July 2008 in “Dermatologic Therapy”

This study developed and evaluated a photographic scale to assess CCCA pattern and severity in African American women, finding it reproducible when used by investigators and participants.

research Female Pattern Hair Loss and Its Relationship to Permanent/Cicatricial Alopecia: A New Perspective

73 citations , November 2005 in “Journal of Investigative Dermatology Symposium Proceedings”

This article reviews the potential relationship between different forms of permanent hair loss such as cicatricial pattern hair loss and discusses related conditions, reporting no new clinical findings.

research Hair Density in African Americans

129 citations , June 1999 in “Archives of Dermatology”

This study found that hair density is significantly lower in African Americans compared to whites, which may affect the evaluation and diagnosis of scalp biopsy specimens in this population.

research Diagnostic and Predictive Value of Horizontal Sections of Scalp Biopsy Specimens in Male Pattern Androgenetic Alopecia

309 citations , May 1993 in “Journal of The American Academy of Dermatology”

This study concluded that horizontal sections of scalp biopsy specimens provide more diagnostic information for male pattern androgenetic alopecia than vertical sections and can predict hair regrowth potential following topical minoxidil therapy.

research Hot Comb Alopecia

107 citations , September 1968 in “Archives of Dermatology”

In this study, researchers identified a form of irreversible scalp alopecia in Black women using hot combs, characterized by incomplete hair loss primarily on the crown and follicular scarring.