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GlossaryParakeratosis

retention of nuclei in the skin's outermost layer

Parakeratosis is a skin condition where the outermost layer of the skin, known as the stratum corneum, retains its nuclei, which is not typical. Normally, these cells lose their nuclei as they move to the surface and become part of the protective barrier. This condition can be seen in various skin disorders, such as psoriasis, and indicates an abnormality in the skin's maturation process.

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research Causes of Parakeratosis in Buffalo Calves in Sharkia Governorate and Treatment Trial

March 2025 in “Egyptian Journal of Animal Health”

Zinc deficiency causes parakeratosis in buffalo calves, and supplementation improves symptoms.

research Granular Parakeratosis of the Eccrine Ostium: A Case Report

July 2023 in “Clinical Cosmetic and Investigational Dermatology”

Accurate diagnosis of granular parakeratosis is crucial for effective treatment and improvement.

research Intracorneal Vacuoles in Skin Diseases with Parakeratotic Hyperkeratosis in Dogs: A Retrospective Light Microscopy Study of 111 Cases (1973–2000)

7 citations , February 2002 in “Veterinary Dermatology”

Intracorneal vacuoles are common in parakeratotic skin diseases in dogs, especially with more parakeratosis.

research The Histopathologic Spectrum of Psoriasis

111 citations , November 2007 in “Clinics in Dermatology”

Psoriasis skin changes are complex and might need several biopsies for a clear diagnosis.

Suprabasal Desmoglein 3 Expression in the Epidermis of Transgenic Mice Results in Hyperproliferation and Abnormal Differentiation

research Suprabasal Desmoglein 3 Expression in the Epidermis of Transgenic Mice Results in Hyperproliferation and Abnormal Differentiation

108 citations , July 2002 in “Molecular and cellular biology”

Overexpressing Dsg3 in mice skin causes excessive cell growth and abnormal skin development.

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community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.