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GlossaryParakeratosis

retention of nuclei in the skin's outermost layer

Parakeratosis is a skin condition where the outermost layer of the skin, known as the stratum corneum, retains its nuclei, which is not typical. Normally, these cells lose their nuclei as they move to the surface and become part of the protective barrier. This condition can be seen in various skin disorders, such as psoriasis, and indicates an abnormality in the skin's maturation process.

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research The Histopathologic Spectrum of Psoriasis

111 citations, November 2007 in “Clinics in Dermatology”

Psoriasis skin changes are complex and might need several biopsies for a clear diagnosis.

Suprabasal Desmoglein 3 Expression in the Epidermis of Transgenic Mice Results in Hyperproliferation and Abnormal Differentiation

research Suprabasal Desmoglein 3 Expression in the Epidermis of Transgenic Mice Results in Hyperproliferation and Abnormal Differentiation

108 citations, July 2002 in “Molecular and cellular biology”

Overexpressing Dsg3 in mice skin causes excessive cell growth and abnormal skin development.

research Neutrophil Gelatinase-Associated Lipocalin Is a Marker for Dysregulated Keratinocyte Differentiation in Human Skin

96 citations, December 2002 in “Experimental dermatology”

NGAL indicates abnormal skin cell differentiation.

research Pathologic Diagnosis of Central Centrifugal Cicatricial Alopecia on Horizontal Sections

29 citations, September 2014 in “American Journal of Dermatopathology”

Horizontal sections of scalp biopsies are good for diagnosing Central Centrifugal Cicatricial Alopecia and help customize treatment.

research Hair Casts and Cutaneous Spicules in Multiple Myeloma

19 citations, December 2006 in “Archives of dermatology”

Hair casts and cutaneous spicules can be signs of multiple myeloma.

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community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 4 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.