Primary Cicatricial Alopecias

    October 2012 in “ Dermatologic Clinics ”
    Nina Otberg
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    TLDR Early diagnosis and aggressive treatment are key for managing rare scalp disorders that cause permanent hair loss.
    The document from 2013 provides an overview of Primary Cicatricial Alopecias (PCAs), a group of rare inflammatory scalp disorders that lead to permanent hair loss due to the destruction of hair follicle stem cells. It emphasizes the importance of early diagnosis and aggressive treatment to manage these conditions. The document classifies PCAs into lymphocytic, neutrophilic, and mixed groups based on the predominant inflammatory cells involved and details the clinical presentation, pathology, risk factors, and management of various PCAs, including Chronic Cutaneous Lupus Erythematosus (DLE), Lichen Planopilaris (LPP), Pseudopelade of Brocq (PPB), Central Centrifugal Cicatricial Alopecia (CCCA), Alopecia Mucinosa (AM), Keratosis Follicularis Spinulosa Decalvans (KFSD), Folliculitis Decalvans (FD), Dissecting Folliculitis (DF), and Acne Keloidalis. It outlines treatment options such as hydroxychloroquine, corticosteroids, immunosuppressive therapies, antimalarials, antistaphylococcal antibiotics, isotretinoin, and surgical interventions, with the goal of halting disease progression and addressing cosmetic concerns. Images provided by Dr. Jerry Shapiro from the UBC Hair Clinic in Vancouver, British Columbia, Canada, support the document.
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