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Platelet-Rich Plasma (PRP) may help improve hair density in primary cicatricial alopecias (PCAs) patients, but more trials are needed to confirm its benefits.

The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.

There are many treatments for permanent hair loss disorders, but their effectiveness varies and there's no clear best option.

Permanent hair loss from cicatricial alopecia is treated by reducing inflammation and managing symptoms, but regrowth in scarred areas is unlikely.

Early diagnosis and aggressive treatment are key for managing rare scalp disorders that cause permanent hair loss.