Fibroproliferative Genes Are Preferentially Expressed in Central Centrifugal Cicatricial Alopecia

    April 2018 in “ Journal of Investigative Dermatology ”
    Crystal Aguh, O. Dina, Luis A. Garza
    TLDR CCCA may be a fibroproliferative disorder, and anti-fibrotic therapies could help.
    The study investigated the gene expression in central centrifugal cicatricial alopecia (CCCA), a condition predominantly affecting black women, characterized by hair loss and fibrosis. By analyzing gene expression in scalp tissue from 5 patients, researchers found that 1270 fibroproliferative genes were preferentially expressed in CCCA, with significant upregulation of genes related to extracellular matrix organization and collagen modeling. This suggests that CCCA may be a fibroproliferative disorder similar to systemic sclerosis and keloids. The findings indicated that anti-fibrotic therapies could potentially benefit CCCA patients, highlighting a need for further research in this area.
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