Lichen Planopilaris: Retrospective Study on the Characteristics and Treatment of 291 Patients

November 2018 in “ Journal of dermatological treatment ”

Hamid Babahosseini, Soheil Tavakolpour, Hamidreza Mahmoudi, Kamran Balighi, Amir Teimourpour, Seyede-Zahra Ghodsi, Robabeh Abedini, Narges Ghandi, Vahideh Lajevardi, Amin Kiani, Kambiz Kamyab, Mohammad-Reza Mohammadi, Maryam Daneshpazhooh

lichen planopilaris hair loss scarring corticosteroids immunosuppressive agents autoimmune disease LPP steroids immune suppressants

TLDR Women are more likely to have Lichen planopilaris, and treatments with cyclosporine and methotrexate are most effective but less safe than mycophenolate mofetil.

The retrospective study on 291 patients with lichen planopilaris (LPP) conducted by the Autoimmune Bullous Diseases Research Center at Tehran University of Medical Sciences aimed to characterize the disease and evaluate treatment outcomes. The study found that LPP predominantly affected middle-aged women and was associated with significant hair loss and scarring. Various treatments were assessed, including corticosteroids and immunosuppressive agents, with varying degrees of success. The study highlighted the chronic nature of LPP and the need for ongoing management to control symptoms and prevent progression.

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Research cited in this study

18 / 18 results

research Prevalence of Hormonal and Endocrine Dysfunction in Patients with Lichen Planopilaris: A Retrospective Data Analysis of 168 Patients

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Lichen planopilaris (LPP) is linked to androgen excess, while frontal fibrosing alopecia (FFA) is linked to androgen deficiency.

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Comparison of Systemic Mycophenolate Mofetil with Topical Clobetasol in Lichen Planopilaris: A Parallel-Group, Assessor- and Analyst-Blinded, Randomized Controlled Trial

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Mostly postmenopausal Caucasian women get Frontal Fibrosing Alopecia, which often includes eyebrow loss and has limited treatment success.

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Mycophenolate mofetil was effective for most patients in treating scarring hair loss, but some had side effects.

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No treatment showed clear superiority for lichen planopilaris.

research Lichen Planopilaris: Chronic Scarring Alopecia with Autoimmune Component

90 citations , July 2008 in “Dermatologic therapy”

Lichen planopilaris is a chronic, scarring hair loss condition with no definitive cure, requiring accurate diagnosis and treatment to manage symptoms.

research A Histologic Review of 27 Patients with Lichen Planopilaris

76 citations , June 2008 in “Journal of the American Academy of Dermatology”

The conclusion is that certain scalp tissue changes are characteristic of lichen planopilaris, with mucinous perifollicular fibroplasia being a new feature for diagnosis.

research A Case-Series of 29 Patients with Lichen Planopilaris: The Cleveland Clinic Foundation Experience on Evaluation, Diagnosis, and Treatment

113 citations , May 2007 in “Journal of the American Academy of Dermatology”

The study found that steroids and tetracycline helped treat active Lichen planopilaris, and hair transplants were good for later stages.

research Frontal Fibrosing Alopecia: A Survey in 16 Patients

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The study found that Frontal Fibrosing Alopecia affects a broader age range of women and early treatment can help stop hair loss.

research Frontal Fibrosing Alopecia in Postmenopausal Women

179 citations , December 2004 in “Journal of The American Academy of Dermatology”

Some postmenopausal women with frontal fibrosing alopecia stopped losing hair with finasteride treatment, hinting at a possible hormonal cause.

research Primary Cicatricial Alopecias: Clinicopathology of 112 Cases

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