Frontal Fibrosing Alopecia and Genital Lichen Sclerosus: Single-Center Experience

    Sara Grassi, Giulia Tadiotto Cicogna, Francesca Magri, Maria Caterina Fortuna, Gemma Caro, Angelina Pernazza, G. Soda, Emanuele Miraglia, Sandra Giustini, Marta Carlesimo, Alfredo Rossi
    Image of study
    TLDR Frontal fibrosing alopecia may be linked to genital Lichen sclerosus through an autoimmune process.
    This study aimed to enhance the understanding of Frontal fibrosing alopecia (FFA) by examining its epidemiology, clinical features, and comorbidities in a retrospective analysis of 119 Caucasian patients (111 female, 8 male) from 2003 to 2019. The study found that 16% of patients had cutaneous, mucosal, or nail localization of Lichen planus (LP), and 10.61% had concomitant genital Lichen sclerosus (LS), with 4.38% presenting both LS and LP alongside FFA. The findings suggested a potential autoimmune process linking LS and FFA, highlighting the need for further research to understand this association.
    Discuss this study in the Community →

    Research cited in this study

    14 / 14 results

    Related Community Posts Join

    6 / 370 results
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 2 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Fibrosing alopecia in a pattern distribution

      in Research/Science  14 upvotes 7 months ago
      A user has been experiencing hair loss for 4 years, with treatments like minoxidil, finasteride, and various supplements proving ineffective. They were diagnosed with fibrosing alopecia in a pattern distribution, a condition that may require a combination of anti-inflammatory and hair growth treatments.

      community How essential is scalp biopsy when dealing with hair loss?

      in Treatment  5 upvotes 1 week ago
      The user experienced hair loss despite using Fin and Min for 12 years and switched to Dutasteride, RU58841, and Keto scalp serum, but shedding and itch persist. They are considering increasing Dutasteride to 2.5mg and questioning the necessity of a scalp biopsy, with mixed opinions on its usefulness.

      community We Need A Solution For The Inflammatory Response related To AGA

      in Research/Science  16 upvotes 2 months ago
      The conversation is about finding a solution for scalp inflammation related to AGA, with the user expressing frustration that Minoxidil and Finasteride do not address inflammation. The user has researched glucocorticoids and topical NSAIDs for reducing inflammation and seeks advice from specialists.

      community 9 months on Fin - no progress , should I get on Dutasteride?

      in Chat  10 upvotes 3 days ago
      The user has been using finasteride, minoxidil, and nizoral for hair loss but hasn't seen regrowth, only maintenance. They are considering switching to dutasteride, which is believed to be more effective, but are concerned about potential side effects.

      community Testosterone and hair loss seeming irrelevance

      in Research/Science  81 upvotes 1 year ago
      The conversation is about the role of testosterone in hair loss and the effectiveness of different treatments. The conclusion is that DHT is the main culprit for hair loss, and finasteride has been proven to work long-term in maintaining and regrowing hair. Testosterone may have a minor effect, but it is not the primary cause of hair loss.

    Related Research

    3 / 3 results