Frontal Fibrosing Alopecia: An Observational Single-Center Study of 306 Cases

June 2023 in “ Life ”

Marcos Carmona‐Rodríguez, Fernando Moro‐Bolado, G. Romero-Aguilera, Ricardo Ruiz‐Villaverde, Víctor Carriel

frontal fibrosing alopecia FFA hypothyroidism lichen planopilaris androgenetic alopecia facial papules itching inflammatory signs autoimmune mechanism androgenic alopecia inflammation autoimmune

Studysummary In this retrospective study, researchers at a Spanish hospital found that the severity of frontal fibrosing alopecia, primarily affecting postmenopausal women, was correlated with the duration of the disease, though inflammatory signs were not linked with its progression.

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research Frontal Fibrosing Alopecia in Men: A Multicenter Study of 39 Patients

5 citations , September 2021 in “Journal of The American Academy of Dermatology”

This study found a high prevalence of beard and eyebrow alopecia in male patients with frontal fibrosing alopecia, and suggests a potential link between hormonal imbalances and the condition.

research Frontal Fibrosing Alopecia: A Review

23 citations , April 2021 in “Journal of Clinical Medicine”

This review compiles existing data on frontal fibrosing alopecia and highlights the promise of 5-alpha reductase inhibitors as a treatment option, while noting the need for clarity on its cause and progression.

research Frontal Fibrosing Alopecia and Genital Lichen Sclerosus: Single-Center Experience

10 citations , June 2020 in “Journal of Cosmetic Dermatology”

This study found a high prevalence of genital Lichen sclerosus and autoimmune comorbidities in patients with frontal fibrosing alopecia, suggesting a possible shared autoimmune process.

research Frontal Fibrosing Alopecia Shows Robust T Helper 1 and Janus Kinase 3 Skewing

34 citations , June 2020 in “British journal of dermatology/British journal of dermatology, Supplement”

In this study, researchers observed that follicular damage and stem cell loss in frontal fibrosing alopecia may be mediated by immune attacks at the bulge region, suggesting potential for JAK/STAT-targeting treatments to prevent progression.

research A Novel Atypical Presentation of Frontal Fibrosing Alopecia Involving the Frontoparietal Scalp

4 citations , January 2020 in “Skin appendage disorders”

This case report describes a unique presentation of frontal fibrosing alopecia characterized by a hair loss pattern that resembles the Greek letter upsilon, supported by trichoscopic and histological findings.

research Clinical-Histopathological Profile of the Frontal Fibrosing Alopecia: A Retrospective Study of 16 Cases at a University Hospital

7 citations , August 2019 in “Anais Brasileiros de Dermatologia”

This study describes the demographic, clinical, and histopathological characteristics of 16 patients with frontal fibrosing alopecia and emphasizes the need for further research on its pathogenesis and treatment.

research Frontal Fibrosing Alopecia: Demographic and Clinical Characteristics of 490 Cases

53 citations , June 2019 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

This study observed that abnormal hormone levels were associated with lower disease activity in frontal fibrosing alopecia, while thyroid disorders were a common comorbidity among the affected population.

Facial and Extrafacial Lesions in an Ethnically Diverse Series of 91 Patients with Frontal Fibrosing Alopecia Followed at a Single Center

research Facial and Extrafacial Lesions in an Ethnically Diverse Series of 91 Patients with Frontal Fibrosing Alopecia Followed at a Single Center

17 citations , November 2018 in “Dermatology”

The authors concluded that Hispanic/Latino ethnicity, facial papules, and premenopausal status in patients with frontal fibrosing alopecia may indicate a susceptibility to more severe disease, potentially necessitating early treatment.

research Familial Frontal Fibrosing Alopecia: A Cross-Sectional Study of 20 Cases from Nine Families

8 citations , November 2018 in “Australasian Journal of Dermatology”

This study adds evidence suggesting a genetic component to frontal fibrosing alopecia, with daughters experiencing an earlier onset than their mothers, although the clinical pattern remains similar to non-familial cases.

research Updated Diagnostic Criteria for Frontal Fibrosing Alopecia

30 citations , December 2017 in “Journal of The American Academy of Dermatology”

This correspondence discusses proposed updates to the diagnostic criteria for frontal fibrosing alopecia, emphasizing the importance of differentiating it from other types of alopecia.

research Unusual Patterns of Presentation of Frontal Fibrosing Alopecia: A Clinical and Trichoscopic Analysis of 98 Patients

18 citations , June 2017 in “Journal of The American Academy of Dermatology”

In this study, trichoscopy consistently identified typical findings of frontal fibrosing alopecia, revealing three unusual clinical patterns in 18.4% of patients, which may aid in the differential diagnosis when clinical presentations are atypical.

research Frontal Fibrosing Alopecia: Clinical and Prognostic Classification

74 citations , April 2017 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

This study classified frontal fibrosing alopecia patients into three clinical patterns, finding that pattern III had the best prognosis and pattern II the worst after treatment with dutasteride and corticosteroids.

research Isolated Eyebrow Loss in Frontal Fibrosing Alopecia: Relevance of Early Diagnosis and Treatment

27 citations , May 2016 in “British journal of dermatology/British journal of dermatology, Supplement”

research Frontal Fibrosing Alopecia and Vitiligo: Coexistence or True Association

31 citations , January 2016 in “Skin Appendage Disorders”

This study observed two cases of frontal fibrosing alopecia developing on preexisting vitiligo, suggesting a potential causal link between the two conditions.

research It's Not All Traction: The Pseudo 'Fringe Sign' in Frontal Fibrosing Alopecia

39 citations , July 2015 in “British Journal of Dermatology”

This article discusses the pseudo 'fringe sign' in frontal fibrosing alopecia, highlighting that it is not solely related to traction, and it reports no new clinical results.

research Frontal Fibrosing Alopecia: A Multicenter Review of 355 Patients

339 citations , February 2014 in “Journal of The American Academy of Dermatology”

This study found that eyelash loss, facial papules, and body hair involvement were linked to severe frontal fibrosing alopecia, and antiandrogens were the most effective treatment.

research Is Hair Transplantation Indicated in Frontal Fibrosing Alopecia? The Results of Test Grafting in Three Patients

45 citations , April 2013 in “Dermatologic surgery”

Hair transplantation might work for some people with frontal fibrosing alopecia, but more research is needed.

research Frontal Fibrosing Alopecia: A Retrospective Review of 19 Patients Seen at Duke University

98 citations , January 2013 in “Journal of The American Academy of Dermatology”

This study reported that while various treatments for frontal fibrosing alopecia showed limited effectiveness, dutasteride most effectively stabilized the condition among patients at Duke University.

research Estrogen Leads to Reversible Hair Cycle Retardation Through Inducing Premature Catagen and Maintaining Telogen

42 citations , July 2012 in “PLOS ONE”

This study found that estrogen can cause reversible suppression of the hair cycle by inducing premature catagen and maintaining the telogen phase without damaging the hair follicle stem cell niche or the signature gene expressions of dermal papilla cells.

research Frontal Fibrosing Alopecia: A Review of 60 Cases

166 citations , April 2012 in “Journal of The American Academy of Dermatology”

This study reviewed clinical data from 60 patients with frontal fibrosing alopecia and found increasing prevalence and generally poor response to treatment, with the cause remaining unclear.

research Hair Loss Due to Lichen Planopilaris After Hair Transplant: Case Reports and Literature Review

22 citations , April 2011 in “Anais Brasileiros de Dermatologia”

This report describes two cases where lichen planopilaris may have compromised the hair follicles in both donor and recipient areas following follicular unit transplantation.

research Frontal Fibrosing Alopecia: A Clinical Review of 36 Patients

159 citations , August 2010 in “British journal of dermatology/British journal of dermatology, Supplement”

In this study, hydroxychloroquine significantly reduced signs and symptoms of frontal fibrosing alopecia after 6 months of treatment, with maximal benefits observed within the first 6 months.

research Treatment of Postmenopausal Frontal Fibrosing Alopecia with Oral Dutasteride

64 citations , June 2009 in “Journal of The American Academy of Dermatology”

This article discusses frontal fibrosing alopecia, noting potential connections to lichen planopilaris, but reports no new clinical findings.

research Frontal Fibrosing Alopecia: Clinical Presentations and Prognosis

155 citations , September 2008 in “British journal of dermatology/British journal of dermatology, Supplement”

This study observed that frontal fibrosing alopecia predominantly affects postmenopausal women, can be associated with lichen planus, and may lead to progressive hairline recession, though this progression is not consistent in all cases.

research Frontal Fibrosing Alopecia: Treatment with Oral Dutasteride and Topical Pimecrolimus

69 citations , August 2008 in “Journal of The European Academy of Dermatology and Venereology”

Oral dutasteride and topical pimecrolimus can safely and effectively treat Frontal Fibrosing Alopecia, leading to significant hair regrowth.

research Diagnostic and Therapeutic Assessment of Frontal Fibrosing Alopecia

16 citations , January 2007 in “Actas dermo-sifiliográficas/Actas dermo-sifiliográficas”

This review discusses frontal fibrosing alopecia and reports no clinical results; the authors note that no therapeutic options tested, including corticosteroids, finasteride, and minoxidil, have shown clear benefits.

research Frontal Fibrosing Alopecia Versus Lichen Planopilaris: A Clinicopathological Study

126 citations , April 2006 in “International Journal of Dermatology”

This study found that frontal fibrosing alopecia and lichen planopilaris have similar histopathological features, but FFA exhibits more prominent apoptosis and less inflammation with spared interfollicular epidermis.

research Frontal Fibrosing Alopecia: A Survey in 16 Patients

123 citations , August 2005 in “Journal of the European Academy of Dermatology and Venereology”

In this study, the researchers observed that treatment with intralesional and topical corticosteroids, finasteride, and minoxidil may stop the progression of frontal fibrosing alopecia in postmenopausal and premenopausal women.

research Frontal Fibrosing Alopecia Developing After Hair Transplantation for Androgenetic Alopecia

64 citations , January 2005 in “International Journal of Dermatology”

This report discusses cases of frontal fibrosing alopecia developing after hair transplantation for androgenetic alopecia, without presenting new clinical findings.

research Postmenopausal Frontal Fibrosing Alopecia: A Frontal Variant of Lichen Planopilaris

329 citations , January 1997 in “Journal of the American Academy of Dermatology”

This study reports that progressive frontal fibrosing alopecia, a distinct and gradually stabilizing form of lichen planopilaris affecting elderly women and often involving eyebrow hair loss, lacks effective treatments.

research Postmenopausal Frontal Fibrosing Alopecia

325 citations , June 1994 in “Archives of Dermatology”

This study observed that progressive frontal recession in postmenopausal women may exhibit features of fibrosing alopecia, suggesting a distinct reaction pattern from typical lichen planopilaris.

research Postmenopausal Frontal Fibrosing Alopecia: Scarring Alopecia in a Pattern Distribution

332 citations , June 1994 in “Archives of Dermatology”

This study found that progressive frontal hairline recession in postmenopausal women may exhibit features similar to fibrosing alopecia, with histologic similarities to lichen planopilaris but lacking lesions of lichen planus.