Clinical-Histopathological Profile of the Frontal Fibrosing Alopecia: A Retrospective Study of 16 Cases at a University Hospital

August 2019 in “ Anais Brasileiros de Dermatologia ”

Pedro Secchin, Danielle Carvalho Quintella, Nathalia Ávila de Oliveira Paula, Luana Cristina da Silva Andrade, Celso Tavares Sodré

frontal fibrosing alopecia autoimmune conditions pathogenesis

TLDR More research is needed to understand and treat frontal fibrosing alopecia.

The study provided a demographical, clinical, and histopathological analysis of 16 patients diagnosed with frontal fibrosing alopecia, a disease of unknown origin often linked with autoimmune conditions. The findings supported existing literature but highlighted the need for further research to understand the disease's pathogenesis and to develop effective treatments.

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Research cited in this study

20 / 20 results

research Efficacy of Isotretinoin and Acitretin in Treatment of Frontal Fibrosing Alopecia: Retrospective Analysis of 54 Cases

26 citations , October 2017 in “PubMed”

Isotretinoin and acitretin may effectively stabilize the hairline in patients with frontal fibrosing alopecia.

research Update on Frontal Fibrosing Alopecia

2 citations , April 2017 in “Actas Dermo-Sifiliográficas”

Best treatment for Frontal Fibrosing Alopecia is 5-alpha-reductase inhibitors and intralesional corticosteroids.

research Primary Cicatricial Alopecia: Treatment Approaches and Classification

95 citations , November 2016 in “Journal of The American Academy of Dermatology”

Treatments for permanent hair loss from scarring aim to stop further loss, not regrow hair, and vary by condition, with partial success common.

research Frontal Fibrosing Alopecia: Reflections and Hypotheses on Etiology and Pathogenesis

68 citations , May 2016 in “Experimental dermatology”

FFA's causes may include environmental triggers and genetic factors.

research Isolated Eyebrow Loss in Frontal Fibrosing Alopecia: Relevance of Early Diagnosis and Treatment

27 citations , May 2016 in “British journal of dermatology/British journal of dermatology, Supplement”

research Frontal Fibrosing Alopecia Treatment Options

20 citations , January 2016 in “Intractable & Rare Diseases Research”

Combination therapy, especially with finasteride, is effective for treating frontal fibrosing alopecia.

research Case Series of Familial Frontal Fibrosing Alopecia and a Review of the Literature

33 citations , January 2015 in “Journal of Cosmetic Dermatology”

Familial frontal fibrosing alopecia affects premenopausal women too, and early diagnosis is important, but no proven medication exists yet.

research Trichoscopic Features of Frontal Fibrosing Alopecia: Results in 249 Patients

46 citations , January 2015 in “Journal of The American Academy of Dermatology”

Trichoscopy helps diagnose and assess the severity of Frontal Fibrosing Alopecia.

research Frontal Fibrosing Alopecia: A Retrospective Clinical Review of 62 Patients with Treatment Outcome and Long-Term Follow-Up

102 citations , April 2014 in “International Journal of Dermatology”

The treatment helped reduce symptoms and stabilize the hairline in most patients with Frontal Fibrosing Alopecia, but hair regrowth was limited.

research Frontal Fibrosing Alopecia: A Multicenter Review of 355 Patients

339 citations , February 2014 in “Journal of The American Academy of Dermatology”

Most patients with frontal fibrosing alopecia are postmenopausal women, and treatments like finasteride and dutasteride can improve or stabilize the condition.

research Treatment of Frontal Fibrosing Alopecia and Lichen Planopilaris: A Systematic Review

117 citations , March 2013 in “Journal of the European Academy of Dermatology and Venereology”

No effective treatment for frontal fibrosing alopecia was found, but oral 5-alpha-reductase inhibitors had the best response; for lichen planopilaris, topical corticosteroids were commonly used but had a high relapse rate.

research Frontal Fibrosing Alopecia and Lichen Planus Pigmentosus: Is There a Link?

86 citations , July 2012 in “British journal of dermatology/British journal of dermatology, Supplement”

There may be a connection between Frontal Fibrosing Alopecia and Lichen Planus Pigmentosus, and more research is needed to confirm this.

research An Atlas of Hair Pathology with Clinical Correlations

45 citations , May 2012 in “CRC Press eBooks”

The book helps doctors better understand and treat hair disorders due to gaps in their training.

research Frontal Fibrosing Alopecia: A Review of 60 Cases

166 citations , April 2012 in “Journal of The American Academy of Dermatology”

Mostly postmenopausal Caucasian women get Frontal Fibrosing Alopecia, which often includes eyebrow loss and has limited treatment success.

research Frontal Fibrosing Alopecia: A Clinical Review of 36 Patients

159 citations , August 2010 in “British journal of dermatology/British journal of dermatology, Supplement”

Hydroxychloroquine effectively reduces symptoms of frontal fibrosing alopecia, especially in the first 6 months.

research An Atlas of Hair Pathology with Clinical Correlations

1 citations , September 2003 in “Journal of the Royal Society of Medicine”

The book is a detailed guide on hair and scalp diseases, useful for dermatopathologists.

research Postmenopausal Frontal Fibrosing Alopecia

57 citations , January 2003 in “Clinical and experimental dermatology”

Postmenopausal frontal fibrosing alopecia is a type of hair loss in postmenopausal women that may stop on its own but has no effective treatment.

research Postmenopausal Frontal Fibrosing Alopecia: A Frontal Variant of Lichen Planopilaris

329 citations , January 1997 in “Journal of the American Academy of Dermatology”

Frontal fibrosing alopecia is a hair loss condition in postmenopausal women, similar to lichen planopilaris, with ineffective treatments.

research Postmenopausal Frontal Fibrosing Alopecia: Scarring Alopecia in a Pattern Distribution

332 citations , June 1994 in “Archives of Dermatology”

Postmenopausal frontal fibrosing alopecia may be a unique condition linked to postmenopausal changes.

research Postmenopausal Frontal Fibrosing Alopecia

325 citations , June 1994 in “Archives of Dermatology”

Postmenopausal frontal fibrosing alopecia may be a unique condition linked to postmenopausal changes.

Related Community Posts Join

6 / 674 results

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

nkrata in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community DUPA/Retrograde might not be DHT based...GET A BIOPSY QUICK or permanent Hair Loss!

in Research/Science 39 upvotes 1 year ago

DUPA and retrograde alopecia may not be solely DHT-based, and a biopsy is crucial for accurate diagnosis and treatment. Treatments mentioned include dutasteride, oral minoxidil, pioglitazone, clobetasol, calcipotriol, ketoconazole, and doxycycline, depending on the specific condition.

community Dutasteride Isn't Working? Get a Scalp Biopsy NOW

in Finasteride/Dutasteride 19 upvotes 1 year ago

Dutasteride may not be effective for everyone due to underlying issues, suggesting scalp biopsies for further diagnosis. Users discuss using higher doses of dutasteride, topical treatments, minoxidil, and pyrilutamide for hair loss management.

community Scalp tension and thickness of the galea aponeurotica, inflammation and potential treatment pathways

in Research/Science 3 years ago

Scalp tension potentially affecting hair loss, and potential treatments for male pattern baldness such as Minoxidil, Finasteride and RU58841. Evidence from a study was discussed which suggests that the cause of MPB lies within the follicle itself and is not dependent on its surrounding environment.

community Quote from Pelage (PP-405) Spokesperson...

in Research/Science 120 upvotes 5 months ago

Pelage is developing a topical hair follicle stem cell therapy, PP405, for non-scarring alopecias like androgenetic alopecia, with Phase III trials planned and a potential market launch by 2027. The treatment may not require continuous use after initial regrowth.

community How essential is scalp biopsy when dealing with hair loss?

in Treatment 6 upvotes 1 year ago

The user experienced hair loss despite using Fin and Min for 12 years and switched to Dutasteride, RU58841, and Keto scalp serum, but shedding and itch persist. They are considering increasing Dutasteride to 2.5mg and questioning the necessity of a scalp biopsy, with mixed opinions on its usefulness.

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Alopecia areata is an autoimmune disease causing patchy hair loss, often with other autoimmune disorders, but its exact causes are unknown.

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research Treating Resistant Cases of Alopecia Universalis

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research Overview of Alopecia Areata

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Alopecia areata is a genetic and immune-related hair loss condition that is often associated with other autoimmune diseases and does not typically cause permanent damage to hair follicles.