Frontal Fibrosing Alopecia in Asians: A Retrospective Clinical Study

    October 2019 in “ International Journal of Dermatology ”
    Poonkiat Suchonwanit, Kallapan Pakornphadungsit, Kanchana Leerunyakul, Saranya Khunkhet, Tueboon Sriphojanart, Salinee Rojhirunsakool
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    TLDR The study concluded that combination therapy with topical corticosteroids and hydroxychloroquine or finasteride is effective in treating Frontal fibrosing alopecia in Asians.
    The retrospective clinical study by Suchonwanit et al. investigated Frontal fibrosing alopecia (FFA) in 56 Thai patients, predominantly female (96.4%), with an average age of onset at 51.3 years. The study found that all patients had frontotemporal hairline recession, and a significant majority (87.5%) also suffered from eyebrow loss. Trichoscopic examination of 35 patients revealed common signs such as follicular dropout, perifollicular erythema, and lonely hair. The most effective treatment for disease stabilization was a combination of topical corticosteroids with hydroxychloroquine (79.3% stabilization) or finasteride (73.3% stabilization). The study suggested that FFA in Asians has mixed clinical patterns and that environmental factors and personal care products might contribute to the condition. It also highlighted the effectiveness of combination therapy in managing FFA, despite the study's limitations, including its retrospective design, single-center approach, and lack of a control group.
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      in Research  830 upvotes 6 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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      Topical finasteride and minoxidil are not effective for the user, who is considering switching to oral treatments like finasteride or dutasteride. Many suggest oral medications are more effective, and some recommend additional treatments like microneedling and other topical solutions.

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