Plasma Rich in Growth Factors as an Adjuvant Treatment for the Management of Frontal Fibrosing Alopecia: A Retrospective Observational Clinical Study

May 2023 in “ Journal of Cutaneous Medicine and Surgery ”

Alejandro García, Monte Navarro, Ana Ramírez, Ander Pino, Ariadna Navarro, Isabel Moles, Estefanía Gallego, Eduardo Anitua

Plasma Rich in Growth Factors PRGF Frontal Fibrosing Alopecia FFA hair loss

Studysummary This study found that combining plasma rich in growth factors with conventional treatment significantly improved hair regrowth and reduced symptoms in patients with frontal fibrosing alopecia compared to conventional treatment alone.

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This retrospective observational clinical study suggests that the adjuvant use of Plasma Rich in Growth Factors (PRGF) may have long-term beneficial effects in managing Frontal Fibrosing Alopecia (FFA). The study indicates that PRGF could help reduce hair loss and alleviate the symptoms and severity associated with FFA.

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Research cited in this study

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research Platelet-Rich Plasma for Treatment-Resistant Frontal Fibrosing Alopecia: A Case Report

15 citations , August 2019 in “Dermatologic Therapy”

This letter details a case report on platelet-rich plasma treatment for a patient with treatment-resistant frontal fibrosing alopecia, but it does not provide new clinical results.

research Platelet-Rich Plasma and Its Utilities in Alopecia: A Systematic Review

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This research review found that platelet-rich plasma treatment generally produced successful hair regrowth in both androgenetic alopecia and alopecia areata, despite study differences that limited direct statistical comparison.

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research Frontal Fibrosing Alopecia: An Update on the Hypothesis of Pathogenesis and Treatment

38 citations , January 2019 in “International Journal of Women's Dermatology”

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research Frontal Fibrosing Alopecia: An Update on Pathogenesis, Diagnosis, and Treatment

61 citations , January 2019 in “American Journal of Clinical Dermatology”

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28 citations , August 2018 in “Dermatologic Surgery”

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12 citations , June 2018 in “Journal of Cosmetic Dermatology”

This review outlines recent research on platelet-rich plasma, alone or combined with other therapies, for managing hair loss disorders, and discusses future prospects without reporting new clinical findings.

The Effect of Plasma Rich in Growth Factors Combined with Follicular Unit Extraction Surgery for the Treatment of Hair Loss: A Pilot Study

research The Effect of Plasma Rich in Growth Factors Combined with Follicular Unit Extraction Surgery for the Treatment of Hair Loss: A Pilot Study

12 citations , October 2017 in “Journal of Cosmetic Dermatology”

This study found that plasma rich in growth factors (PRGF) as an adjuvant to follicular unit extraction (FUE) surgery may enhance hair graft performance and reduce post-surgical inflammation and pain in hair loss patients.

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In this study, a patient with lichen planopillaris experienced complete resolution of itching and hair shedding following treatment with a new platelet-rich plasma regimen, marking the first reported success in this context.

research Management of Androgenetic Alopecia: A Comparative Clinical Study Between Plasma Rich in Growth Factors and Topical Minoxidil

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This study found that plasma rich in growth factors was a safe and more effective treatment for androgenetic alopecia than topical minoxidil, showing greater improvements in hair growth phases.

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This study reviewed clinical data from 60 patients with frontal fibrosing alopecia and found increasing prevalence and generally poor response to treatment, with the cause remaining unclear.

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This study observed that frontal fibrosing alopecia predominantly affects postmenopausal women, can be associated with lichen planus, and may lead to progressive hairline recession, though this progression is not consistent in all cases.

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