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Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia

research Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia

416 citations , September 1997 in “Journal of Investigative Dermatology”

People with hair loss have more androgen receptors and enzymes in certain follicles, with men and women showing different patterns.

research Different keratin polypeptides in epidermis and other epithelia of human skin: a specific cytokeratin of molecular weight 46,000 in epithelia of the pilosebaceous tract and basal cell epitheliomas.

277 citations , October 1982 in “The Journal of Cell Biology”

This study found that the cytokeratin patterns in skin epithelia can distinguish between different types, with basal-cell epitheliomas showing a striking similarity to the pilosebaceous tract.

research Differential expression of retinoic acid-synthesizing (RALDH) enzymes during fetal development and organ differentiation in the mouse

232 citations , January 2002 in “Mechanisms of development”

This study reports that the differential expression patterns of three retinaldehyde dehydrogenases suggest a regulated need for retinoic acid synthesis in various organs during late mouse organogenesis.

research Differences in Hair Follicle Dermal Papilla Volume are Due to Extracellular Matrix Volume and Cell Number: Implications for the Control of Hair Follicle Size and Androgen Responses

231 citations , December 1999 in “Journal of Investigative Dermatology”

This study found that the volume of a hair follicle's dermal papilla is strongly correlated with its size, primarily due to the number of cells it contains and the volume of extracellular matrix.

research The complement of native α-keratin polypeptides of hair-forming cells: A subset of eight polypeptides that differ from epithelial cytokeratins

198 citations , October 1986 in “Differentiation”

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Community Join

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community diffuse thinning is so much worse than recession

14 upvotes 6 days ago

The conversation discusses hair loss treatments, specifically using 2.5mg dutasteride, minoxidil, and sometimes RU58841, with a focus on diffuse thinning versus recession. It also touches on the impact of estrogen levels on hair density.

community Difference between two pics is 3 months and 1 week, is this progress?

4 upvotes 2 weeks ago

The user has been using a regimen of 1mg finasteride daily, minoxidil foam 5% twice a day, and recently added oral Dutasteride 0.5 mg once a week, showing noticeable progress in hair growth over 3 months and 1 week. The feedback is positive, encouraging consistency and patience for continued improvement.

community Diffuse thinner, would I respond well to a hair transplant?

29 upvotes 3 weeks ago

The user is experiencing diffuse thinning and has started taking 0.5mg dutasteride and 5mg oral minoxidil daily, planning to wait a year before considering a hair transplant. They are advised to be patient, consult with doctors, and see how the medication affects their hair density before proceeding with surgery.

community Diffuse hair shedding + recurrent scalp burning/inflammation — looking for similar experiences

4 weeks ago

The user experienced scalp burning and diffuse hair shedding after surgery, with symptoms worsening due to factors like weather changes and stress. They tried minoxidil and finasteride but stopped due to side effects, and found some relief with corticosteroid scalp treatments while correcting vitamin deficiencies.

community Diffuse thinner 10 weeks progress on oral fin + topical min

108 upvotes 1 month ago

A user shared their 10-week progress using oral finasteride and topical minoxidil for hair loss, reporting significant improvement with no side effects from finasteride and increased body hair from minoxidil. Others in the conversation noted varying results with similar treatments.

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Learn

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learn Nanoxidil

Key Differences between minoxidil and nanoxidil? Nanoxidil has a lower molecular weight than minoxidil, enhancing absorption and reducing side effects.

learn Ketoconazole

Is there a difference between 1% and 2% ketoconazole? The documented differences are strength and supply: 1% ketoconazole shampoo is sold over the counter while 2% is usually prescription-only, and almost all of the trial evidence — including a 2015 Cochrane review — was gathered on the 2% shampoo rather than in a head-to-head comparison of the two strengths.

learn RU58841

RU58841: What's the difference between minoxidil and finasteride? Minoxidil stimulates hair growth, while finasteride reduces DHT levels to prevent hair loss.

learn Aminexil

How is Aminexil different from the classic minoxidil? Is one gentler? Aminexil is gentler than minoxidil and may have fewer side effects.

learn Fluridil

How is Fluridil different from other DHT blockers like finasteride? Fluridil is a topical androgen-receptor blocker applied to the scalp, while finasteride is an oral 5-alpha-reductase inhibitor that lowers DHT throughout the body. Finasteride is FDA-approved and far better studied; Fluridil rests on one 43-man trial and is not licensed as a hair-loss medicine, so its long-term safety and effect size are unknown.

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