Tumor Necrosis Factor-Induced Alopecia: Alternative Pathology and Therapy

The document discussed cases of alopecia induced by TNF inhibitors used to treat Crohn disease and psoriasis. It described a woman who developed alopecia and scalp psoriasis during infliximab therapy, which resolved after discontinuing the drug and starting oral and topical treatments. The study compared this case with another where alopecia was induced by adalimumab, noting different histopathologic features. Both patients fully recovered, but with different treatment approaches: one continued adalimumab with intralesional triamcinolone acetonide, while the other discontinued infliximab and used topical therapies and oral minocycline. The conclusion emphasized the variability in histopathology and the effectiveness of multiple therapeutic options for TNF-inhibitor induced alopecia.