In Situ Formed Fluorescent Gold Nanoclusters Inhibit Hair Follicle Regeneration in Oxidative Stress Microenvironment via Suppressing NFκB Signal Pathway

    March 2024 in “ Chinese Chemical Letters ”
    Xiangdong Lai, Tengfei Liu, Zengchao Guo … Xuemei Wang
    Studysummary In this study, researchers demonstrated that zero valence fluorescent gold nanoclusters can be biosynthesized in damaged skin and inhibit hair follicle regeneration by affecting the NFκB inflammatory response pathway, suggesting potential as a treatment for hypertrichosis related to skin injury.
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    Research cited in this study 16

    1. 3,4,5-Tri-O-Caffeoylquinic Acid Promoted Hair Pigmentation Through β-Catenin and Its Target Genes Frontiers in cell and developmental biology · 2020
    2. Hes1 Regulates Anagen Initiation and Hair Follicle Regeneration Through Modulation of Hedgehog Signaling Stem Cells · 2019
    3. Hair Follicle Development in Mouse Pluripotent Stem Cell-Derived Skin Organoids Cell Reports · 2018
    4. NF-κB Participates in Mouse Hair Cycle Control and Plays Distinct Roles in Various Pelage Hair Follicle Types ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2017
    5. Macrophages Induce AKT/β-Catenin-Dependent Lgr5+ Stem Cell Activation and Hair Follicle Regeneration Through TNF Nature Communications · 2017
    6. Androgen Excess: Investigations and Management Best Practice & Research in Clinical Obstetrics & Gynaecology · 2016
    7. Interventions for Hirsutism Excluding Laser and Photoepilation Therapy Alone: Abridged Cochrane Systematic Review Including GRADE Assessments British journal of dermatology/British journal of dermatology, Supplement · 2016
    8. Organ-Level Quorum Sensing Directs Regeneration in Hair Stem Cell Populations Cell · 2015
    9. Reflections on How Wound Healing-Promoting Effects of the Hair Follicle Can Be Translated into Clinical Practice Experimental Dermatology · 2014
    10. Update on Idiopathic Hirsutism: Diagnosis and Treatment Acta Clinica Belgica · 2013
    11. Fgf9 From Dermal γδ T Cells Induces Hair Follicle Neogenesis After Wounding Nature Medicine · 2013
    12. The Hirsute Woman: Challenges in Evaluation and Management Endocrine Practice · 2011
    13. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    14. The Hair Cycle Journal of Cell Science · 2006
    15. Hypertrichosis Journal of the American Academy of Dermatology · 2003
    16. Melanogenesis Is Coupled to Murine Anagen: Toward New Concepts for the Role of Melanocytes and the Regulation of Melanogenesis in Hair Growth ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1993

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    1. Regeneration of Hair Follicles Is Modulated by Flightless I (Flii) in a Rodent Vibrissa Model Journal of Investigative Dermatology · 2010