Vorasidenib-Induced Trichomegaly and Hypertrichosis: A New Side Effect in a Patient with Diffuse Astrocytoma

August 2024 in “ Dermatology and Therapy ”

Michela Starace, Stephano Cedirian, Luca Rapparini, Francesca Bruni, Bianca Maria Piraccini

vorasidenib trichomegaly hypertrichosis androgenetic alopecia scalp hair regrowth

Studysummary This report describes a case where a 44-year-old male treated with vorasidenib for diffuse low-grade gliomas developed unexpected hair growth, including in areas of severe hair loss, after one month, highlighting a previously undocumented side effect. Our plain-language summary of this paper — not a Tressless recommendation.

A 44-year-old male with diffuse astrocytoma experienced trichomegaly and hypertrichosis, including scalp hair regrowth in areas of severe androgenetic alopecia, after one month of vorasidenib treatment. This case highlights a previously unreported side effect of vorasidenib, an IDH1/2 inhibitor, which may be linked to elevated α-KG levels promoting hair follicle regeneration. The findings underscore the need for careful monitoring of novel therapies for brain tumors to optimize treatment strategies and improve patient care.

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research Stimulation of Hair Growth by Small Molecules That Activate Autophagy

88 citations , June 2019 in “Cell reports”

This study found that activating autophagy with specific small molecules and drugs can stimulate hair growth by initiating the anagen phase in dormant hair follicles, suggesting a potential treatment for hair loss.