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GlossaryMicroenvironment

localized environment surrounding cells or tissues

The term "microenvironment" refers to the specific, localized environment surrounding cells or tissues, including factors like nutrients, oxygen levels, and signaling molecules. In the context of hair and alopecia, the hair follicle microenvironment includes the cells, extracellular matrix, and biochemical signals that influence hair growth and health. Understanding this microenvironment is crucial for developing treatments for hair loss conditions.

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Biological and Mechanical Influence of Three-Dimensional Microenvironment Formed in Microwell on Multicellular Spheroids Composed of Heterogeneous Hair Follicle Stem Cells

research Biological and Mechanical Influence of Three-Dimensional Microenvironment Formed in Microwell on Multicellular Spheroids Composed of Heterogeneous Hair Follicle Stem Cells

1 citations, December 2023 in “Scientific reports”

3D microenvironments in microwells improve hair follicle stem cell behavior and hair regeneration.

research Identification of Stem Cell Populations in Sweat Glands and Ducts Reveals Roles in Homeostasis and Wound Repair

265 citations, July 2012 in “Cell”

The study found that sweat glands contain different types of stem cells that help with healing and maintaining healthy skin.

research Concise Review: The Plasticity of Stem Cell Niches: A General Property Behind Tissue Homeostasis and Repair

50 citations, December 2013 in “Stem Cells”

Stem cell niches are adaptable and key for tissue maintenance and repair.

research Building and Maintaining the Skin

22 citations, October 2021 in “Cold Spring Harbor Perspectives in Biology”

Three types of stem cells help maintain and repair skin, responding to health and environmental changes.

research Multifunctional Photoactive Hydrogels for Wound Healing Acceleration

227 citations, December 2021 in “ACS Nano”

Special hydrogels that respond to light can speed up wound healing and prevent infection.

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community Polydopamine Synergizes with Quercetin Nanosystem to Reshape the Perifollicular Microenvironment for Accelerating Hair Regrowth in Androgenetic Alopecia.

in Research/Science 13 upvotes 7 months ago

A quercetin-encapsulated and polydopamine-integrated nanosystem (PDA@QLipo) shows promise for treating androgenetic alopecia by reshaping the perifollicular microenvironment, outperforming minoxidil in hair regeneration. The nanosystem promotes cell proliferation, hair follicle renewal, and recovery by scavenging reactive oxygen species and enhancing neovascularity.

community So we have 20k dollars human like machines available but no new effective treatment for hairloss since finasteride :)

in Chat 237 upvotes 2 months ago

There have been no new effective hair loss treatments since finasteride, despite technological advancements. Current treatments include finasteride, minoxidil, and RU58841, with ongoing challenges and potential future solutions in research.

community New Research- Creatine Increasing Scalp DHT Without Corresponding Serum DHT Increase

in Research/Science 120 upvotes 6 months ago

Creatine may increase scalp DHT without affecting serum DHT, potentially speeding up male pattern baldness (MPB) for those genetically prone. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community New Treatments, and a Huge Group Buy with Lots of Research

in Research/Science 109 upvotes 1 year ago

A user is organizing a group buy for various compounds aimed at reversing hair loss and gray hair, and improving brain health and fat loss. The user has developed a treatment plan based on extensive research and is inviting others to participate, with the option to choose only the compounds they need.

community Why I really believe the tension theory is the cause of MPB

in Research/Science 70 upvotes 3 years ago

The conversation discusses the tension theory as a cause of male pattern baldness (MPB), suggesting that scalp tension and reduced subcutaneous fat layer contribute to hair loss. Treatments mentioned include Minoxidil, finasteride, microneedling, scalp massages, and Botox.

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