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GlossaryMicroenvironment

localized environment surrounding cells or tissues

The term "microenvironment" refers to the specific, localized environment surrounding cells or tissues, including factors like nutrients, oxygen levels, and signaling molecules. In the context of hair and alopecia, the hair follicle microenvironment includes the cells, extracellular matrix, and biochemical signals that influence hair growth and health. Understanding this microenvironment is crucial for developing treatments for hair loss conditions.

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Biological and Mechanical Influence of Three-Dimensional Microenvironment Formed in Microwell on Multicellular Spheroids Composed of Heterogeneous Hair Follicle Stem Cells

research Biological and Mechanical Influence of Three-Dimensional Microenvironment Formed in Microwell on Multicellular Spheroids Composed of Heterogeneous Hair Follicle Stem Cells

1 citations, December 2023 in “Scientific reports”

3D microenvironments in microwells improve hair follicle stem cell behavior and hair regeneration.

research Identification of Stem Cell Populations in Sweat Glands and Ducts Reveals Roles in Homeostasis and Wound Repair

265 citations, July 2012 in “Cell”

The study found that sweat glands contain different types of stem cells that help with healing and maintaining healthy skin.

research Concise Review: The Plasticity of Stem Cell Niches: A General Property Behind Tissue Homeostasis and Repair

50 citations, December 2013 in “Stem Cells”

Stem cell niches are adaptable and key for tissue maintenance and repair.

research Building and Maintaining the Skin

22 citations, October 2021 in “Cold Spring Harbor Perspectives in Biology”

Three types of stem cells help maintain and repair skin, responding to health and environmental changes.

research Imaging Tumor Angiogenesis With Fluorescent Proteins

21 citations, July 2004 in “Apmis”

Fluorescent proteins help visualize and understand tumor blood vessel growth.

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community Polydopamine Synergizes with Quercetin Nanosystem to Reshape the Perifollicular Microenvironment for Accelerating Hair Regrowth in Androgenetic Alopecia.

in Research/Science 13 upvotes 8 months ago

A quercetin-encapsulated and polydopamine-integrated nanosystem (PDA@QLipo) shows promise for treating androgenetic alopecia by reshaping the perifollicular microenvironment, outperforming minoxidil in hair regeneration. The nanosystem promotes cell proliferation, hair follicle renewal, and recovery by scavenging reactive oxygen species and enhancing neovascularity.

community So we have 20k dollars human like machines available but no new effective treatment for hairloss since finasteride :)

in Chat 237 upvotes 3 months ago

There have been no new effective hair loss treatments since finasteride, despite technological advancements. Current treatments include finasteride, minoxidil, and RU58841, with ongoing challenges and potential future solutions in research.

community New Research- Creatine Increasing Scalp DHT Without Corresponding Serum DHT Increase

in Research/Science 119 upvotes 8 months ago

Creatine may increase scalp DHT without affecting serum DHT, potentially speeding up male pattern baldness (MPB) for those genetically prone. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 5 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community New Treatments, and a Huge Group Buy with Lots of Research

in Research/Science 109 upvotes 1 year ago

A user is organizing a group buy for various compounds aimed at reversing hair loss and gray hair, and improving brain health and fat loss. The user has developed a treatment plan based on extensive research and is inviting others to participate, with the option to choose only the compounds they need.

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