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Glossary Hair Stem Cell Markers

specific proteins identifying hair follicle stem cells

Hair stem cell markers are specific proteins or molecules found on the surface of hair follicle stem cells. These markers help scientists identify and isolate these stem cells, which are crucial for hair growth and regeneration. For example, markers like CD34 and K15 are commonly used to pinpoint hair follicle stem cells in research and therapeutic applications.

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Research

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research From hair to pancreas: transplanted hair follicle mesenchymal stem cells express pancreatic progenitor cell markers in a rat model of acute pancreatitis.

8 citations , January 2021 in “PubMed”

This study suggests that hair follicle-derived mesenchymal stem cell transplantation may effectively treat acute pancreatitis by reducing inflammation and promoting pancreatic regeneration in a rat model.

research Hair follicle stem cell marker nestin expression in regenerating hair follicles of patients with alopecia areata

6 citations , March 2011 in “European Journal of Dermatology”

This study observed that nestin-positive, K15-negative cells in hair follicles may play a crucial role in hair follicle regeneration in patients with alopecia areata.

research Behavior of Human Foreskin Keratinocytes Expressing a Hair Follicle Stem Cell Marker CD200

12 citations , November 2007 in “Journal of Investigative Dermatology”

CD200 is not a reliable marker for identifying stem cells in all skin types.

research Epidermal retinol dehydrogenases cyclically regulate stem cell markers and clock genes and influence hair composition

April 2024 in “Communications biology”

The researchers reported that disrupting ATRA signaling by deleting RDHE genes in the hair follicle led to altered hair follicle cycles, composition, and gene expression, indicating RDHEs' role in hair follicle signaling coordination.

research Delayed Cutaneous Wound Healing and Aberrant Expression of Hair Follicle Stem Cell Markers in Mice Selectively Lacking Ctip2 in Epidermis

52 citations , February 2012 in “PloS one”

This study found that the absence of Ctip2 in epidermal keratinocytes led to impaired wound healing in mice, affecting cell migration, proliferation, and hair follicle stem cell maintenance.

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Community Join

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community Researchers working on ways to regenerate lost hair from stem cells identified a recipe for normal hair regeneration in the lab. “A method for cyclical regeneration of hair follicles from hair follicle stem cells and will help make hair follicle regeneration therapy a reality in the near future.”

263 upvotes 5 years ago

Hair loss treatments like finasteride, minoxidil, and hair transplants have side effects and limitations. There is hope for future advancements in stem cell therapy and hair follicle regeneration, though skepticism about their effectiveness and timeline persists.

community New Light Therapy Can Suppress a Key Marker of Hair Loss by 92%

in Research/Science 201 upvotes 5 months ago

A new light therapy claims to reduce hair loss markers by 92% using a specific wavelength range. Users discuss the cost and effectiveness of devices, with some expressing skepticism and others considering alternative treatments like red light therapy and vitamin D exposure.

community Eirion Therapeutics Announces Potential Breakthrough Treatment for Hair Loss Based on First-in-Man Clinical Trial Results

in Update 415 upvotes 1 year ago

ET-02, a new hair loss treatment, shows promising results with a 6-fold increase in hair count, potentially outperforming minoxidil by activating stem cells in hair follicles. Further trials are ongoing to confirm its efficacy and safety, with potential market release in the future.

community A Theory on Why Microneedling Works

175 upvotes 7 years ago

Microneedling may enhance hair regrowth by transferring stem cells to dormant follicles, improving the effects of minoxidil. Users discuss using microneedling with needle lengths around 1.5mm to stimulate hair growth.

community New Hair Loss Cure: AMP-303 Is Back. It’s what PP405 should have been.

7 upvotes 6 months ago

AMP-303 and AMP-601 are new hair loss treatments targeting dermal papilla cells, with AMP-303 showing early efficacy in transitioning vellus hairs to terminal hairs after one injection. Further clinical trials are planned, and these treatments are seen as promising due to their biologic approach and less frequent application compared to daily treatments.

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Learn

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learn Stem Cell Factor

Does stem cell factor help activate dormant hair follicles? Lab and mouse studies link stem cell factor to hair colour; it has not been shown to reactivate dormant hair follicles in people.
Can stem cell factor be combined with other topical hair loss solutions? No published human trial has tested topical stem cell factor alongside minoxidil or other established treatments, so neither the safety nor the benefit of the combination has been established. Community users report layering these products, but that is anecdote rather than clinical evidence.
What is stem cell factor and why is it used in hair growth treatments? Stem cell factor is a signalling protein linked to hair colour in lab and mouse studies; it is not a proven hair-loss treatment in people.
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learn Hair Transplant

Can a hair transplant be combined with other treatments? Clinics commonly say a transplant is combined with other treatments, most often minoxidil, finasteride or PRP, but the evidence behind each add-on differs. Some of the add-ons offered, such as stem-cell or exosome products, are not approved treatments for hair loss.

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extract, clone, and reinsert your own hair cells

learn SCUBE3

Signalling protein made in the hair follicle

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mitochondrial pyruvate carrier (MPC) inhibitor by Pelage in early trials

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Cosmetic ingredient made by L'Oréal

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Clinics

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