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Did you mean JAK-STAT signaling pathway?

GlossaryJAK-STAT pathway

transmits signals from cell surface to nucleus for gene expression

The JAK-STAT pathway, short for Janus kinase-signal transducer and activator of transcription pathway, is a chain of interactions between proteins in a cell that transmits signals from chemical signals outside the cell to the cell nucleus, resulting in DNA transcription and activity changes. This pathway is crucial for regulating immune function, cell growth, and development, and has been implicated in various diseases, including certain types of alopecia and cancers.

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Titrated Extract of Centella Asiatica Increases Hair Inductive Property Through Inhibition of STAT Signaling Pathway in Three-Dimensional Spheroid Cultured Human Dermal Papilla Cells

research Titrated Extract of Centella Asiatica Increases Hair Inductive Property Through Inhibition of STAT Signaling Pathway in Three-Dimensional Spheroid Cultured Human Dermal Papilla Cells

13 citations, October 2017 in “Bioscience, Biotechnology, and Biochemistry”

Centella asiatica extract may help promote hair growth by blocking a specific cell signaling pathway.

Particulate Matter Induces Inflammatory Response in Human Outer Root Sheath Cells via Oxidative Stress-Dependent MAPK and JAK-STAT Signaling Pathways

research Particulate Matter Induces Inflammatory Response in Human Outer Root Sheath Cells via Oxidative Stress-Dependent MAPK and JAK-STAT Signaling Pathways

July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Particulate matter causes inflammation in hair cells, potentially harming hair growth.

research The JAK/STAT Signaling Pathway: From Bench to Clinic

489 citations, November 2021 in “Signal Transduction and Targeted Therapy”

The JAK/STAT pathway is important in cell processes and disease, and JAK inhibitors are promising for treating related conditions.

Hair Growth-Promoting Effects of Enz MoriL on Human Dermal Papilla Cells Through Modulation of the Wnt/β-Catenin and JAK-STAT Signaling Pathways

research Hair Growth-Promoting Effects of Enz MoriL on Human Dermal Papilla Cells Through Modulation of the Wnt/β-Catenin and JAK-STAT Signaling Pathways

May 2024 in “Archives of dermatological research”

Enz_MoriL from mulberry leaves helps hair growth by affecting specific cell pathways.

research Oncostatin M Is Upstream of JAK-STAT Signaling During the Murine Hair Cycle

April 2016 in “Journal of Investigative Dermatology”

Blocking Oncostatin M's role in the JAK-STAT pathway can stimulate hair growth in mice.

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community What else is good. Besides the big 3.

in Chat 34 upvotes 2 months ago

Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

community Why do I have the feeling that this subreddit is flooded by Kintor employees?

in Chat 132 upvotes 4 months ago

Users discuss aggressive promotion of Koshine 826, suspecting Kintor employees are behind it. Concerns are raised about its effectiveness, with some preferring alternatives like finasteride and minoxidil.

community Sometimes, the problem is the hair structure…

in Progress Pictures 165 upvotes 3 months ago

A 24-year-old shared his hair loss journey, using finasteride and topical minoxidil for 6 months with positive results and no side effects. He recommends growing hair out and getting a good haircut to improve appearance and confidence.

community Oral min vs topical comparison

in Treatment 10 upvotes 2 months ago

Oral minoxidil is claimed to be more effective and easier to use than topical minoxidil, with a 100% response rate, but it may cause unwanted body hair growth and has potential heart-related side effects. Topical minoxidil is less effective for many due to enzyme limitations, can cause scalp issues, and is more challenging to apply, but it avoids systemic side effects.

community Density loss after 4 months on DUTASTERIDE, does it get better if you stick with it?

in Finasteride/Dutasteride 3 upvotes 6 months ago

A user experienced increased hair density loss after 4 months on dutasteride combined with finasteride. They are also using topical dutasteride with azelaic acid and alfatradiol but cannot tolerate antiandrogens like RU58841 due to headaches.

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