A New Strategy to Modulate Alopecia Using a Combination of Two Specific and Unique Ingredients
May 2013
in “
PubMed
”
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Studysummary In this randomized, placebo-controlled study, the tested cosmetic ingredient containing Trifolium pratense flower extract and a biomimetic peptide increased anagen hair and improved the anagen/telogen ratio over four months in individuals with recessing hair.
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In a randomized, placebo-controlled study conducted 11 years ago, a combination of Trifolium pratense flower extract and a biomimetic peptide was tested on 30 volunteers with receding hair for the prevention of hair loss. After 4 months of daily topical application, anagen (growth phase) hair increased by 13%, telogen (resting phase) hair density decreased by 29%, and the anagen/telogen ratio increased by 46% over baseline in the treated group. These results were significantly different from the placebo group. The positive effects on hair growth were attributed to the inhibition of 5-α-reductase activity, reduction of inflammatory reactions, and stimulation of extracellular matrix protein synthesis in the vicinity of the hair follicle.
