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    Did you mean 4-Hydroxycyclophosphamide?
    Glossary 4-Hydroxycyclophosphamide

    active metabolite of cyclophosphamide used in chemotherapy

    4-Hydroxycyclophosphamide (4-HC) is an active metabolite of the chemotherapy drug cyclophosphamide. It is formed in the liver and is responsible for the drug's therapeutic effects, as well as some of its side effects. 4-HC works by interfering with the DNA of rapidly dividing cells, which makes it effective in treating certain cancers and autoimmune diseases.

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    Research 30 of 1000+

    1. Dissecting the Impact of Chemotherapy on the Human Hair Follicle ˜The œAmerican journal of pathology · 2007 · 99 citations
    2. Peroxisome proliferator-activated receptor-γ signalling protects hair follicle stem cells from chemotherapy-induced apoptosis and epithelial–mesenchymal transition 2021 · 19 citations
    3. Protective effect of Korean Red Ginseng against chemotherapeutic drug-induced premature catagen development assessed with human hair follicle organ culture model Journal of Ginseng Research · 2015 · 19 citations
    4. Modulation of Chemotherapy-Induced Human Hair Follicle Damage by 17-β Estradiol and Prednisolone: Potential Stimulators of Normal Hair Regrowth by “Dystrophic Catagen” Promotion? Journal of Investigative Dermatology · 2008 · 18 citations
    5. 1409 Temporary cell cycle arrest by ALRN-6924: A novel, p53-targeting strategy to protect human scalp hair follicles against cyclophosphamide-induced alopecia Journal of Investigative Dermatology · 2023
    6. Prevention and Treatment of Chemotherapy-Induced Alopecia: What Is Available and What Is Coming? Current Oncology · 2023 · 4 citations
    7. Priming mobilization of hair follicle stem cells triggers permanent loss of regeneration after alkylating chemotherapy Nature Communications · 2019 · 32 citations
    8. Present Chemotherapy Induced Alopecia and Research in Future Austin therapeutics · 2021
    9. Complex Changes in the Apoptotic and Cell Differentiation Programs during Initiation of the Hair Follicle Response to Chemotherapy Journal of Investigative Dermatology · 2014 · 12 citations
    10. Chemotherapy-Induced Alopecia InTech eBooks · 2012 · 2 citations
    11. Profiling the Response of Human Hair Follicles to Ultraviolet Radiation Journal of Investigative Dermatology · 2009 · 53 citations
    12. Protective Effects of Korean Red Ginseng Against Oxidative Stress-Induced Damage in Human Hair Annals of Dermatology · 2024
    13. Laminin-511, inducer of hair growth, is down-regulated and its suppressor in hair growth, laminin-332 up-regulated in chemotherapy-induced alopecia Journal of dermatological science · 2010 · 13 citations
    14. Controlling Hair Loss by Regulating Apoptosis in Hair Follicles: A Comprehensive Overview Biomolecules · 2023 · 1 citations
    15. Ginseng in Hair Growth and Viability IntechOpen eBooks · 2021
    16. Drug Treatment of Acute Leukaemia Current Status Drugs · 1989
    17. Synthesis and 5α-Reductase Inhibitory Activity of C21 Steroids Having 1,4-diene or 4,6-diene 20-ones and 4-Azasteroid 20-Oximes Molecules · 2011 · 186 citations
    18. The Antiandrogenic Action of 4–Androsten–3–one–17β– Carboxylic Acid and Its Methyl Ester on Hamster Flank Organ1 Endocrinology · 1973 · 87 citations
    19. Involvement of 4‐hydroxy‐2‐nonenal in pollution‐induced skin damage BioFactors · 2019 · 50 citations
    20. [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) inhibits SCF/c-kit signaling in 501mel human melanoma cells and abolishes melanin production in mice and brownish guinea pigs Biochemical Pharmacology · 2007 · 26 citations
    21. 13C-NMR study of 4-azasteroids in solution and solid state Steroids · 2002 · 25 citations
    22. New approach to 3-oxo-4-aza-5α-androst-1-ene-17β-(--butylcarboxamide) Steroids · 2005 · 14 citations
    23. 4 Vitamin D resistance Baillière's clinical endocrinology and metabolism · 1994 · 13 citations
    24. 4-aminopyridine attenuates inflammation and apoptosis and increases angiogenesis to promote skin regeneration following a burn injury in mice Cell Death Discovery · 2024 · 11 citations
    25. 4-(Alkylthio)- and 4-(arylthio)-benzonitrile derivatives as androgen receptor antagonists for the topical suppression of sebum production Bioorganic & Medicinal Chemistry Letters · 2009 · 11 citations
    26. Preparation of 4-aryl-2-trifluoromethylbenzonitrile derivatives as androgen receptor antagonists for topical suppression of sebum production Bioorganic & Medicinal Chemistry Letters · 2007 · 11 citations
    27. Synthesis and Biological Evaluation of 4-(4-(Alkyl-and Phenylaminocarbonyl)benzoyl)benzoic Acid Derivatives as Non-steroidal Inhibitors of Steroid 5α-Reductase Isozymes 1 and 2 Archiv Der Pharmazie · 2002 · 8 citations
    28. 4‐MAPC, a 5α‐Reductase Inhibitor, Reduces Rat Ventral Prostate Weight, DNA, and Prostatein Concentrations Journal of Andrology · 1991 · 7 citations
    29. 4 Anti-androgens in gynaecological practice Baillière's clinical obstetrics and gynaecology · 1988 · 7 citations
    30. 4-<i>O</i>-Methylhonokiol Protects HaCaT Cells from TGF-β1-Induced Cell Cycle Arrest by Regulating Canonical and Non-Canonical Pathways of TGF-β Signaling Biomolecules & Therapeutics · 2017 · 5 citations