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    Glossary Cyclin-Dependent Kinase 4

    regulates cell cycle progression from G1 to S phase

    Cyclin-Dependent Kinase 4 (CDK4) is an enzyme that plays a crucial role in regulating the cell cycle, specifically the transition from the G1 phase to the S phase, where the cell prepares to replicate its DNA. It forms a complex with cyclin D, and this complex is essential for the progression of cells through the cell cycle, making it a key player in cell division and growth. Dysregulation of CDK4 activity is often associated with various cancers, as it can lead to uncontrolled cell proliferation.

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    1. Fatigue, alopecia and stomatitis among patients with breast cancer receiving cyclin-dependent kinase 4 and 6 inhibitors: a systematic review and meta-analysis Expert Review of Anticancer Therapy · 2017 · 28 citations
    2. Safety assessment of cyclin-dependent kinase 4/6 inhibitors and comparison of time to adverse events PLoS ONE · 2025 · 2 citations
    3. Cyclin‐dependent kinase 4 expression alters the number of keratinocyte stem cells in the mouse hair follicle Cell Biology International · 2022 · 1 citations
    4. Cyclin-Dependent Kinase 4/6 Inhibitors and Dermatologic Adverse Events: Results from the EADV Task Force “Dermatology for Cancer Patients” International Study Cancers · 2023 · 1 citations
    5. Abstract 3889: Cyclin-dependent kinase 4 levels affect the number of hair follicle stem cells in mouse epidermis Cancer Research · 2010
    6. Drug repurposing of cyclin-dependent kinase inhibitors for neutrophilic acute respiratory distress syndrome and psoriasis Journal of Advanced Research · 2024 · 8 citations
    7. Poster Presentations at the 28th Joint Meeting of the International Society of Dermatopathology, March 5–6, 2025, Orlando, Florida, USA American Journal of Dermatopathology · 2025
    8. The Effect of EGR1 on the Proliferation of Dermal Papilla Cells Genes · 2022 · 5 citations
    9. CDK4/6 plus aromatase inhibitor-induced alopecia in breast cancer patients. Journal of Clinical Oncology · 2019 · 4 citations
    10. Novel small molecules downregulate CDK1 expression and inhibit Wnt/β-catenin signaling in cutaneous squamous cell carcinoma by targeting its distinct tumor-specific cellular landscape Experimental & Molecular Medicine · 2025
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