Search

for
Search:

GlossaryCyclin-Dependent Kinase 4

regulates cell cycle progression from G1 to S phase

Cyclin-Dependent Kinase 4 (CDK4) is an enzyme that plays a crucial role in regulating the cell cycle, specifically the transition from the G1 phase to the S phase, where the cell prepares to replicate its DNA. It forms a complex with cyclin D, and this complex is essential for the progression of cells through the cell cycle, making it a key player in cell division and growth. Dysregulation of CDK4 activity is often associated with various cancers, as it can lead to uncontrolled cell proliferation.

Related Terms

Sort by

Research

30 / 1000+ results

Fatigue, alopecia and stomatitis among patients with breast cancer receiving cyclin-dependent kinase 4 and 6 inhibitors: a systematic review and meta-analysis

research Fatigue, alopecia and stomatitis among patients with breast cancer receiving cyclin-dependent kinase 4 and 6 inhibitors: a systematic review and meta-analysis

28 citations , July 2017 in “Expert Review of Anticancer Therapy”

Breast cancer patients taking CDK4/6 inhibitors are more likely to experience fatigue, hair loss, and mouth sores.

research Cyclin‐dependent kinase 4 expression alters the number of keratinocyte stem cells in the mouse hair follicle

1 citations , February 2022 in “Cell Biology International”

Changing CDK4 levels affects the number of stem cells in mouse hair follicles.

Cyclin-Dependent Kinase 4/6 Inhibitors and Dermatologic Adverse Events: Results from the EADV Task Force “Dermatology for Cancer Patients” International Study

research Cyclin-Dependent Kinase 4/6 Inhibitors and Dermatologic Adverse Events: Results from the EADV Task Force “Dermatology for Cancer Patients” International Study

1 citations , July 2023 in “Cancers”

Skin side effects from CDK4/6 inhibitors in breast cancer patients are generally mild and treatable, allowing most patients to continue treatment.

research Herbal Extracts Induce Dermal Papilla Cell Proliferation of Human Hair Follicles

24 citations , January 2015 in “Annals of Dermatology”

Herbal extracts may help hair grow and could be an alternative to synthetic hair loss treatments.

research Molecular Regulation of Melanocyte Senescence

85 citations , July 2002 in “Pigment Cell Research”

The article concludes that while we understand a lot about how melanocytes age and how this can prevent cancer, there are still unanswered questions about certain pathways and genes involved.

Combinatorial expression of cell cycle regulators is more suitable for immortalization than oncogenic methods in dermal papilla cells

research Combinatorial expression of cell cycle regulators is more suitable for immortalization than oncogenic methods in dermal papilla cells

5 citations , January 2021 in “iScience”

Using a combination of specific cell cycle regulators is better for safely keeping hair root cells alive indefinitely compared to cancer-related methods.

research Managing hyperglycemia and rash associated with alpelisib: expert consensus recommendations using the Delphi technique

1 citations , January 2024 in “NPJ breast cancer”

Experts agree on how to manage sugar levels and skin reactions in patients taking the cancer drug alpelisib.

research Human Derived Immortalized Dermal Papilla Cells With a Constant Expression of Testosterone Receptor

8 citations , March 2020 in “Frontiers in Cell and Developmental Biology”

Researchers created immortal human skin cells with constant testosterone receptor activity to study hair loss and test treatments.

research Cyclin D3 deficiency inhibits skin tumor development, but does not affect normal keratinocyte proliferation

2 citations , July 2017 in “Oncology Letters”

Lacking cyclin D3 reduces skin cancer growth without affecting normal skin cell growth.

research Biological Activities of 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-Glucoside in Antiaging and Antiaging-Related Disease Treatments

43 citations , January 2016 in “Oxidative medicine and cellular longevity”

THSG from a Chinese plant helps with aging and related diseases.

research RSPO1-mutated keratinocytes from palmoplantar keratoderma display impaired differentiation, alteration of cell–cell adhesion, EMT-like phenotype and invasiveness properties: implications for squamous cell carcinoma susceptibility in patients with 46XX disorder of sexual development

5 citations , July 2022 in “Orphanet journal of rare diseases”

RSPO1 mutations in certain patients lead to skin cells that don't develop properly and are more likely to become invasive, increasing the risk of skin cancer.

Recent advances on skin‐resident stem/progenitor cell functions in skin regeneration, aging and cancers and novel anti‐aging and cancer therapies

research Recent advances on skin‐resident stem/progenitor cell functions in skin regeneration, aging and cancers and novel anti‐aging and cancer therapies

36 citations , January 2010 in “Journal of Cellular and Molecular Medicine”

New treatments targeting skin stem cells show promise for skin repair, anti-aging, and cancer therapy.

research Wnt and Notch signaling pathway involved in wound healing by targeting c-Myc and Hes1 separately

113 citations , June 2015 in “Stem Cell Research & Therapy”

Wnt and Notch signaling help wound healing by promoting cell growth and regulating cell differentiation.

research Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss

86 citations , July 2020 in “International Journal of Molecular Sciences”

Activating the Wnt/β-catenin pathway could lead to new hair loss treatments.

research Epigallocatechin Gallate-Mediated Alteration of the MicroRNA Expression Profile in 5α-Dihydrotestosterone-Treated Human Dermal Papilla Cells

16 citations , January 2016 in “Annals of Dermatology”

Green tea component EGCG may help prevent hair loss by changing microRNA levels in certain scalp cells.

3-Deoxysappanchalcone Promotes Proliferation of Human Hair Follicle Dermal Papilla Cells and Hair Growth in C57BL/6 Mice by Modulating WNT/β-Catenin and STAT Signaling

research 3-Deoxysappanchalcone Promotes Proliferation of Human Hair Follicle Dermal Papilla Cells and Hair Growth in C57BL/6 Mice by Modulating WNT/β-Catenin and STAT Signaling

26 citations , November 2016 in “Biomolecules & Therapeutics”

3-Deoxysappanchalcone helps human hair cells grow and stimulates hair growth in mice by affecting certain cell signaling pathways.

research Colchicine in Managing Skin Conditions: A Systematic Review

21 citations , January 2022 in “Pharmaceutics”

Colchicine might help treat different skin diseases, but more research is needed to confirm its effectiveness and safe dosage.

Clinical Guidance on the Monitoring and Management of Trastuzumab Deruxtecan (T-DXd)-Related Adverse Events: Insights from an Asia-Pacific Multidisciplinary Panel

research Clinical Guidance on the Monitoring and Management of Trastuzumab Deruxtecan (T-DXd)-Related Adverse Events: Insights from an Asia-Pacific Multidisciplinary Panel

3 citations , August 2023 in “Drug safety”

Proactive monitoring and management are essential to maximize the benefits of Trastuzumab Deruxtecan while minimizing serious side effects.

research Platelet-rich plasma: The journey so far !

18 citations , January 2020 in “Indian Dermatology Online Journal”

Platelet-rich plasma shows potential for hair loss and skin rejuvenation but needs more research for widespread use.

research Abemaciclib-Associated Skin, Hair, and Nail Toxicities: A Case Report

April 2024 in “Curēus”

Abemaciclib can cause skin, hair, and nail problems, leading some patients to stop using it.

research Hormone receptor positive, HER2 negative metastatic breast cancer: Impact of CDK4/6 inhibitors on the current treatment paradigm

4 citations , October 2018 in “Asia-Pacific Journal of Clinical Oncology”

CDK4/6 inhibitors have improved treatment outcomes for certain advanced breast cancer patients.

research Mutant laboratory mice with abnormalities in hair follicle morphogenesis, cycling, and/or structure: An update

52 citations , January 2013 in “Journal of Dermatological Science”

The document concludes that mouse models are crucial for studying hair biology and that all mutant mice may have hair growth abnormalities that require detailed analysis to identify.

research Hair Changes due to Drugs

January 2019 in “Elsevier eBooks”

Some drugs can cause reversible hair loss, but certain chemotherapy drugs may lead to permanent hair loss; drugs can also change hair color and texture.

research Hair Follicle: A Novel Source of Multipotent Stem Cells for Tissue Engineering and Regenerative Medicine

65 citations , August 2013 in “Tissue Engineering Part B-reviews”

Hair follicle stem cells are a promising source for tissue repair and treating skin or hair diseases.

research The C3H/HeJ mouse and DEBR rat models for alopecia areata: review of preclinical drug screening approaches and results

59 citations , September 2008 in “Experimental dermatology”

Both mouse and rat models are effective for testing alopecia areata treatments.

research Cutaneous toxicities of new targeted cancer therapies: must know for diagnosis, management, and patient-proxy empowerment

7 citations , May 2020 in “Annals of palliative medicine”

New targeted cancer drugs can cause skin side effects, and managing them requires patient education and timely care.

research Epidermal homeostasis: a balancing act of stem cells in the skin

1039 citations , February 2009 in “Nature Reviews Molecular Cell Biology”

Skin stem cells are crucial for maintaining and repairing the skin and hair, using a complex mix of signals to do so.

research Potential of nano-phytochemicals in cervical cancer therapy

43 citations , June 2020 in “Clinica chimica acta”

Nano-sized plant-based chemicals could improve cervical cancer treatment by being more effective and causing fewer side effects than current methods.

An Intrinsic Oscillation of Gene Networks Inside Hair Follicle Stem Cells: An Additional Layer That Can Modulate Hair Stem Cell Activities

research An Intrinsic Oscillation of Gene Networks Inside Hair Follicle Stem Cells: An Additional Layer That Can Modulate Hair Stem Cell Activities

23 citations , December 2020 in “Frontiers in Cell and Developmental Biology”

Gene network oscillations inside hair stem cells are key for hair growth regulation and could help treat hair loss.

research Insulin Promotes Corneal Nerve Repair and Wound Healing in Type 1 Diabetic Mice by Enhancing Wnt/β-Catenin Signaling

15 citations , November 2020 in “American Journal of Pathology”

Insulin helps heal corneal wounds and nerves in diabetic mice by activating the Wnt signaling pathway.