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Glossaryp15INK4b

protein that inhibits cell cycle progression to prevent uncontrolled division

p15INK4b, also known as CDKN2B, is a protein that helps regulate the cell cycle by inhibiting certain enzymes called cyclin-dependent kinases (CDKs). This inhibition prevents cells from dividing uncontrollably, which is crucial for preventing cancer. In the context of hair and alopecia, disruptions in the regulation of cell division can affect hair follicle function and growth.

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research Epigenetic Control of Adult Stem Cell Function

179 citations, July 2016 in “Nature Reviews Molecular Cell Biology”

Epigenetic changes control how adult stem cells work and can lead to diseases like cancer if they go wrong.

research Ginseng Phytochemicals as Therapeutics in Oncology: Recent Perspectives

50 citations, February 2018 in “Biomedicine & pharmacotherapy”

Ginseng may help treat cancer and reduce treatment side effects, but more research is needed.

research Cellular Senescence in Tissue Repair: Every Cloud Has a Silver Lining

33 citations, January 2018 in “The International Journal of Developmental Biology”

Cell aging can be both good and bad for tissue repair.

research Oncogenic Senescence: A Multi-Functional Perspective

32 citations, February 2017 in “Oncotarget”

Cellular senescence has both cancer-blocking and cancer-promoting effects, and targeting senescent cells may improve health and lifespan.

research Tailored Chromatin Modulation to Promote Tissue Regeneration

10 citations, May 2019 in “Seminars in Cell & Developmental Biology”

Understanding and manipulating epigenetic changes can potentially lead to human organ regeneration therapies, but more research is needed to improve these methods and minimize risks.

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