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    Glossary p15INK4b

    protein that inhibits cell cycle progression to prevent uncontrolled division

    p15INK4b, also known as CDKN2B, is a protein that helps regulate the cell cycle by inhibiting certain enzymes called cyclin-dependent kinases (CDKs). This inhibition prevents cells from dividing uncontrollably, which is crucial for preventing cancer. In the context of hair and alopecia, disruptions in the regulation of cell division can affect hair follicle function and growth.

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    Research 21

    1. Data from Synergistic Function of Smad4 and PTEN in Suppressing Forestomach Squamous Cell Carcinoma in the Mouse 2023
    2. Data from Synergistic Function of Smad4 and PTEN in Suppressing Forestomach Squamous Cell Carcinoma in the Mouse 2023
    3. Comparison of allogeneic stem cell transplant conditioning regimens in AML, MDS and CLL General internal medicine and clinical innovations · 2018
    4. Epigenetic control of adult stem cell function Nature Reviews Molecular Cell Biology · 2016 · 179 citations
    5. Cellular senescence in tissue repair: every cloud has a silver lining The International Journal of Developmental Biology · 2018 · 33 citations
    6. Oncogenic senescence: a multi-functional perspective Oncotarget · 2017 · 32 citations
    7. Tailored chromatin modulation to promote tissue regeneration Seminars in Cell & Developmental Biology · 2019 · 10 citations
    8. The Role of Histone Demethylases in Disease Springer eBooks · 2011 · 1 citations
    9. Lysocellin, a metabolite of the novel drug ‘alopestatin’, induces G1 arrest and prevents cytotoxicity induced by etoposide International Journal of Oncology · 2006 · 1 citations
    10. Actinic Keratosis: Risk Factors, Clinical, Diagnosis and Therapeutics Aspects. Part I Dermatovenerologiâ, kosmetologiâ · 2024
    11. Aging and Immortality: Quasi-Programmed Senescence and Its Pharmacologic Inhibition Cell Cycle · 2006 · 295 citations
    12. Hedgehog signaling maintains hair follicle stem cell phenotype in young and aged human skin Aging Cell · 2009 · 62 citations
    13. From basic biology to engineered therapies: the keratinocyte stem cell playbook Frontiers in Medical Technology · 2026
    14. Epigenetics of Colorectal Cancer Gastroenterology · 2012 · 218 citations
    15. Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment Development · 2003 · 182 citations
    16. p63 Regulates Human Keratinocyte Proliferation via MYC-regulated Gene Network and Differentiation Commitment through Cell Adhesion-related Gene Network Journal of Biological Chemistry · 2011 · 82 citations
    17. Miz1 is required for hair follicle structure and hair morphogenesis Journal of cell science · 2007 · 33 citations
    18. Changing Incidence Trends of Cutaneous B-Cell Lymphoma Journal of Investigative Dermatology · 2013 · 30 citations
    19. Follistatin promotes LIN28B-mediated supporting cell reprogramming and hair cell regeneration in the murine cochlea Science Advances · 2022 · 16 citations
    20. Metabolic pathways of eicosanoids—derivatives of arachidonic acid and their significance in skin Cellular & Molecular Biology Letters · 2025
    21. Long-Term Effects of Sirolimus on Human Skin TSC2-Null Fibroblast‒Like Cells Journal of Investigative Dermatology · 2021 · 1 citations