TLDR Dog skin with hair loss, when transplanted to mice, regrew hair, suggesting the hair loss cause is likely body-wide, not skin-specific.
In the 2013 study, skin biopsies from lesional and nonlesional areas of two dogs with canine recurrent flank alopecia (cRFA) were transplanted onto five athymic nude mice. The aim was to determine if cRFA was caused by systemic or local factors and to explore the potential for a reproducible disease model. The results showed that both types of grafts regrew hair within 30 days, despite the donor dogs maintaining alopecia in the lesional areas. Two of the mice experienced graft rejection. The loss of lesional hyperpigmentation in the mice suggested that cRFA's pathogenesis is likely systemic. The study concluded that while the xenograft model might not be ideal for studying cRFA, it could be useful for researching other systemic causes of canine alopecia.
45 citations,
December 2009 in “Veterinary dermatology” The book is recommended for its new scientific information and balanced treatment options for hair loss in domestic animals.
17 citations,
May 2003 in “Journal of The American Academy of Dermatology” Hair from balding and non-balding areas regrows similarly on mice.
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8 citations,
February 2005 in “Veterinary dermatology” Chesapeake Bay retrievers' hair loss is likely a breed-specific, hereditary condition linked to abnormal steroid levels and distinct skin changes.
1 citations,
December 2010 in “The journal of small animal practice/Journal of small animal practice” The book helps veterinarians understand and treat hair loss in animals.
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1 citations,
January 2006 in “Elsevier eBooks” The conclusion is that different types of hair loss in dogs and cats can be cosmetic or serious, and affected animals should not be bred.
2 citations,
April 2022 in “Genes” The study found that the hair loss condition in Cesky Fousek dogs is influenced by multiple genes affecting skin and muscle structure, fat metabolism, and immunity.
September 2016 in “Elsevier eBooks” Different types of hair loss in dogs and cats have various causes and treatments, with outcomes ranging from good to uncertain.
