Trilostane Treatment of Canine Alopecia X in an American Pit Bull Terrier

January 2007 in “ Acta Veterinaria Brno ”

J. Kolevská, V. Brunclík, Ladislava Bartošová, M. Svoboda

trilostane alopecia X hormone-responsive dermatosis adrenal sex hormone imbalance ovariohysterectomy

TLDR Trilostane treatment successfully restored hair growth in a dog with alopecia X.

This paper detailed the case of a one-year-old female American Pit Bull Terrier with progressive baldness diagnosed as alopecia X, a hormone-responsive dermatosis. Initial treatment with ovariohysterectomy led to temporary hair regrowth, but symptoms returned more severely. Further hormonal tests indicated an adrenal sex hormone imbalance, leading to trilostane therapy at 8 mg/kg/day, administered twice daily. This treatment resulted in complete hair regrowth within four months, with no adverse effects observed.

View this study on actavet.vfu.cz →

Discuss this study in the Community →

Research cited in this study

5 / 5 results

research The Use of Trilostane for the Treatment of Alopecia X in Alaskan Malamutes

15 citations , September 2005 in “The Journal of the American Animal Hospital Association/Journal of the American Animal Hospital Association”

Trilostane effectively treated hair loss in Alaskan Malamutes with no adverse effects.

research Treatment of Canine Alopecia X with Trilostane

40 citations , October 2004 in “Veterinary Dermatology”

Trilostane treatment led to full hair regrowth in most Pomeranians and all miniature poodles with alopecia X.

research Trilostane Treatment of 78 Dogs With Pituitary-Dependent Hyperadrenocorticism

149 citations , June 2002 in “Veterinary record/The veterinary record”

Trilostane effectively improved symptoms in dogs with a certain adrenal gland disorder.

research Finasteride in the Treatment of Men with Androgenetic Alopecia

581 citations , October 1998 in “Journal of The American Academy of Dermatology”

Finasteride safely and effectively treats male pattern hair loss, but may cause reversible sexual issues and harm male fetuses.

Effect of Finasteride on Serum Concentrations of Dihydrotestosterone and Testosterone in Three Clinically Normal Sexually Intact Adult Male Dogs

research Effect of Finasteride on Serum Concentrations of Dihydrotestosterone and Testosterone in Three Clinically Normal Sexually Intact Adult Male Dogs

10 citations , June 1998 in “PubMed”

Finasteride significantly reduces DHT levels in male dogs without affecting testosterone levels, suggesting it could be used to treat benign prostatic hypertrophy in dogs weighing 10 to 50 kilograms.

Similar Research

5 / 63 results

research Hereditary, Congenital, And Acquired Alopecias

January 2011 in “Elsevier eBooks”

Alopecia in animals can be hereditary, congenital, or acquired, with treatments and outcomes varying widely.

research Hereditary, Congenital, and Acquired Alopecias in Dogs and Cats

1 citations , January 2006 in “Elsevier eBooks”

The conclusion is that different types of hair loss in dogs and cats can be cosmetic or serious, and affected animals should not be bred.

research Hereditary, Congenital, and Acquired Alopecias

September 2016 in “Elsevier eBooks”

Different types of hair loss in dogs and cats have various causes and treatments, with outcomes ranging from good to uncertain.

research Atypical Cushing's Syndrome in Dogs: Arguments For and Against

22 citations , February 2010 in “The Veterinary clinics of North America. Small animal practice/Veterinary clinics of North America. Small animal practice”

The cause of atypical Cushing's syndrome in dogs, possibly linked to sex hormones, is not yet proven.

research Hypotrichosis and Alopecia

July 2019

Accurate diagnosis and tailored treatments are crucial for managing hair loss in humans and animals.