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research Resident human dermal γδT-cells operate as stress-sentinels: Lessons from the hair follicle

27 citations , August 2021 in “Journal of Autoimmunity”

This study found that human dermal γδT-cells can act as stress sentinels and potentially trigger autoimmune responses toward stressed hair follicles, resembling features of alopecia areata.

research 396 Vδ1 + T-cells are stress-sentinels in human skin and are implicated in alopecia areata pathogenesis

1 citations , August 2016 in “Journal of Investigative Dermatology”

This study suggests that human dermal Vδ1+ γδ T-cells may contribute to alopecia areata pathogenesis by targeting stressed scalp hair follicles and inducing immune privilege collapse.

Early Prediction of Alopecia Areata Using Machine Learning Modeling of Neuro Stress Immune Signatures from Multiple Datasets

research Early prediction of alopecia areata using machine learning modeling of neuro stress immune signatures from multi datasets

1 citations , December 2025 in “Scientific Reports”

In this study, researchers developed a predictive model for the onset of alopecia areata by analyzing six datasets to identify key feature genes and employing various machine learning algorithms, ultimately finding the XGBoost model most effective for clinical application.

research Effect of flutamide and two novel synthetic steroids on GABA, glutamine and some oxidative stress markers in rat brain and prostate

2 citations , January 2011 in “Andrologia”

This study concluded that 16β-methyl-17α-benzoyloxypregnen-4-en-3,20-dione may be a promising treatment for androgen-dependent diseases and epilepsy due to its antioxidant effects and impact on GABAergic and serotonergic metabolism in rats.

Tumor Regression Predicts Higher Risk of Sentinel Node Involvement in Thin Cutaneous Melanomas

research Tumour regression predicts higher risk of sentinel node involvement in thin cutaneous melanomas

68 citations , September 2003 in “British Journal of Dermatology”

This study found that in thin cutaneous melanomas, tumor regression is associated with a higher risk of sentinel lymph node involvement.

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Community Join

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community Testosterone in Reference Range Doesn't Cause Hair Loss

52 upvotes 2 years ago

Testosterone within the normal range does not significantly contribute to male pattern baldness (MPB); DHT is the main factor that can be controlled. Genetics play a crucial role in hair loss, and treatments like finasteride and dutasteride, which block DHT, can help despite potentially raising testosterone levels.

community Stress supplements that do not increase shedding?

2 upvotes 10 months ago

Ashwagandha may lower cortisol but can cause hair loss. Alternatives like magnesium are suggested for stress without affecting hair.

community A stress hormone has been found to signal through skin cells to repress the activation of hair-follicle stem cells in mice

30 upvotes 5 years ago

Stress can lead to hair loss by affecting hair-follicle stem cells, and this loss is harder to recover from if one has male pattern baldness (MPB). Treatments like finasteride and minoxidil are used to address hair loss, but stress-related hair loss differs from androgenic alopecia.

community (/r/science X-post): Stress may turn your hair grey. The appearance of grey hairs after periods of stress or skin damage could be the result of depletion of stem cells from the base of the hair follicle, according to a new study : science

4 upvotes 13 years ago

Stress can cause hair to turn grey due to stem cell depletion at the hair follicle base. Treatments discussed include Minoxidil, finasteride, and RU58841 for hair loss.

community High stress causing more shedding perhaps balding? 21(M)

5 upvotes 12 years ago

A 21-year-old male is experiencing hair shedding, possibly due to stress from a breakup, and is using minoxidil and drinking green tea to address it. Others suggest stress as a cause and recommend consulting a dermatologist if it persists.

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Learn

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learn Lavender

Is lavender effective for hormonal hair loss or just stress? Lavender may help with stress-related hair loss but has limited evidence for hormonal hair loss.

learn procapil

Could pairing Procapil with antioxidants be the power combo for stress-induced hair thinning? Procapil combined with antioxidants may effectively combat stress-induced hair thinning.

learn Vitamin B5

Is Vitamin B5 beneficial for people experiencing stress-related or nutritional hair loss? Vitamin B5 is not proven to help with stress-related or nutritional hair loss.

learn Vitamin B6

Is Vitamin B6 helpful for stress-related or hormonal hair loss? Vitamin B6 may support overall health but lacks strong evidence for preventing hair loss.

learn PP405

Got small bald patches they say are from stress? PP405 sprays could help bring them back to life. PP405 is an experimental topical gel from Pelage Pharmaceuticals that inhibits the mitochondrial pyruvate carrier; its registered Phase 2 trial (NCT06393452) tested it once daily in 78 adults with pattern hair loss, for safety and tolerability. It is not approved, not for sale, and has not been studied in alopecia areata or stress-related shedding.

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