The Regulation of Skin Homeostasis, Repair, and the Pathogenesis of Skin Diseases by Spatiotemporal Activation of Epidermal mTOR Signaling

The document reviewed the role of mTOR signaling in skin homeostasis, repair, and disease pathogenesis, emphasizing its importance in processes like barrier formation, hair growth, and skin repair. mTOR signaling, particularly through its complexes mTORC1 and mTORC2, was crucial for epidermal differentiation, tissue growth, and hair follicle stem cell regulation. Dysregulation of mTOR was linked to various skin disorders, including impaired wound healing, psoriasis, and skin cancer. The review highlighted mTOR as a potential therapeutic target, with inhibitors showing promise in treating skin cancers and inflammatory conditions, although the precise mechanisms remained complex and required further research.