The Regulation of Skin Homeostasis, Repair, and the Pathogenesis of Skin Diseases by Spatiotemporal Activation of Epidermal mTOR Signaling

    July 2022 in “ Frontiers in Cell and Developmental Biology ”
    Juan Wang, Baiping Cui, Zhongjian Chen, Xiaolei Ding
    Studysummary This review discusses the role of mTOR signaling in the epidermis, emphasizing its importance in skin processes like barrier formation and wound repair, and reports no new experimental results.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 13

    1. Hair Follicle Stem Cells as a Skin-Organizing Signaling Center During Adult Homeostasis The EMBO Journal · 2021
    2. Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle Cell Metabolism · 2020
    3. Epidermal Mammalian Target of Rapamycin Complex 2 Controls Lipid Synthesis and Filaggrin Processing in Epidermal Barrier Formation Journal of Allergy and Clinical Immunology · 2019
    4. Activation of mTORC1 Signaling Is Required for Timely Hair Follicle Regeneration from Radiation Injury Radiation Research · 2017
    5. Caloric Restriction Promotes Structural and Metabolic Changes in the Skin Cell Reports · 2017
    6. Defining Stem Cell Dynamics and Migration During Wound Healing in Mouse Skin Epidermis Nature Communications · 2017
    7. mTOR Signaling Promotes Stem Cell Activation via Counterbalancing BMP-Mediated Suppression During Hair Regeneration Journal of molecular cell biology/Journal of Molecular Cell Biology · 2015
    8. Immunohistochemical Analysis of the Mechanistic Target of Rapamycin and Hypoxia Signaling Pathways in Basal Cell Carcinoma and Trichoepithelioma PloS one · 2014
    9. Emerging Interactions Between Skin Stem Cells and Their Niches Nature Medicine · 2014
    10. Cell Death by Cornification Biochimica et biophysica acta. Molecular cell research · 2013
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    13. Sgk3 Links Growth Factor Signaling to Maintenance of Progenitor Cells in the Hair Follicle The Journal of Cell Biology · 2005