Immunohistochemical Analysis of the Mechanistic Target of Rapamycin and Hypoxia Signaling Pathways in Basal Cell Carcinoma and Trichoepithelioma

    September 2014 in “ PloS one ”
    Tjinta Brinkhuizen, Chantal A. H. Weijzen, Jonathan Eben, M. R. T. M. Thissen, Arie ̈nne M. van Marion, Bjo ̈ rn G. Lohman, Ve ́ronique J. L. Winnepenninckx, Patty J. Nelemans, M.A.M. van Steensel
    TLDR The study found that analyzing certain cell signaling pathways is not a reliable method to tell apart two types of skin tumors.
    The study conducted an immunohistochemical analysis of the mTOR and hypoxia signaling pathways in basal cell carcinoma (BCC) and trichoepithelioma (TE) using 45 BCC and 35 TE samples. Both tumor types exhibited significant activation of the mTOR pathway, with BCC showing higher activation levels. Hypoxia-inducible factor 1-alpha (HIF-1α) was upregulated in BCC, indicating a role of hypoxia signaling in its pathogenesis. The findings suggested that while these pathways are active in both BCC and TE, they do not serve as reliable diagnostic tools to distinguish between the two, but they do highlight potential therapeutic targets for BCC.
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