Expression of Nidogen1 in Basal Cell Carcinoma

    April 2018 in “ Journal of Investigative Dermatology ”
    Y. Hirakawa, Sugiko Futaki, Hideaki Tanizaki, Kentaro Maemura, Fukumi Furukawa, Shinichi Moriwaki
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    TLDR Higher levels of nidogen1 and type IV collagen are found in basal cell carcinoma compared to normal skin.
    The document presents findings from various studies on skin cancer and hair growth. One study focused on basal cell carcinoma (BCC), a type of skin cancer, and investigated the expression of nidogen1, a component of the basement membrane. The study, which included 5 BCC samples, found that nidogen1 and another basement membrane protein, type IV collagen (Col4), were expressed at higher levels in BCC compared to normal skin, suggesting that these proteins may play a role in the development of BCC. Another study reported on a clinical phase I/IIa study of FOL-005, a peptide that promotes hair growth. Subcutaneous injections of FOL-005 were found to be safe and resulted in an 8% increase in hair growth at one of the doses tested. The distribution of FOL-005 in mice skin was tracked using MALDI-MSI technology, showing that the peptide was distributed exclusively in the treated skin and degraded locally, supporting its development as a treatment for alopecia. Other studies in the document discussed the regulation of proliferation in infantile hemangioma, genetic transformations in squamous cell carcinoma following chemotherapy, and the mutational landscape of extramammary Paget disease.
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