Expression of Nidogen1 in Basal Cell Carcinoma
April 2018
in “
Journal of Investigative Dermatology
”
Studysummary The study found that, unlike in actinic keratosis and squamous cell carcinoma, basal cell carcinoma tissues showed higher expression of nidogen1 and Col4 in both basement membranes and surrounding stroma compared to normal skin. Our plain-language summary of this paper — not a Tressless recommendation.
The document presents findings from various studies on skin cancer and hair growth. One study focused on basal cell carcinoma (BCC), a type of skin cancer, and investigated the expression of nidogen1, a component of the basement membrane. The study, which included 5 BCC samples, found that nidogen1 and another basement membrane protein, type IV collagen (Col4), were expressed at higher levels in BCC compared to normal skin, suggesting that these proteins may play a role in the development of BCC. Another study reported on a clinical phase I/IIa study of FOL-005, a peptide that promotes hair growth. Subcutaneous injections of FOL-005 were found to be safe and resulted in an 8% increase in hair growth at one of the doses tested. The distribution of FOL-005 in mice skin was tracked using MALDI-MSI technology, showing that the peptide was distributed exclusively in the treated skin and degraded locally, supporting its development as a treatment for alopecia. Other studies in the document discussed the regulation of proliferation in infantile hemangioma, genetic transformations in squamous cell carcinoma following chemotherapy, and the mutational landscape of extramammary Paget disease.
