WNT Signaling in Disease

    August 2019 in “ Cells ”
    Li Fang Ng, Paramdeep Kaur, Nawat Bunnag, Jahnavi Suresh, Isabelle Chiao Han Sung, Qian Tan, Jan Gruber, Nicholas S. Tolwinski
    Image of study
    TLDR The WNT signaling pathway is important in many diseases and targeting it could offer new treatments.
    The document from August 3, 2019, reviews the WNT signaling pathway's role in a variety of human diseases, including cancer, Alzheimer's, metabolic syndrome, and others. It explains how mutations in WNT pathway components can lead to diseases, such as colorectal cancer, where about 80% of cases involve mutations in the APC gene. The review also discusses the potential of WNT signaling in aging and its effects on hair graying and bone healing. It highlights the complexity of WNT signaling, its crosstalk with other pathways, and the therapeutic potential of targeting this pathway. For instance, the document mentions the FDA-approved drugs vismodegib and erismodegib for basal cell cancers and a topical treatment, SM04554, in Phase II clinical trials for androgenetic alopecia that has shown increased hair follicle counts. The review underscores the importance of a balanced approach to manipulating WNT signaling in disease treatment, considering the "Goldilocks hypothesis" where the level of WNT signaling must be neither too high nor too low.
    Discuss this study in the Community →

    Research cited in this study

    4 / 4 results

    Related Community Posts Join

    6 / 90 results

      community Better Than Minoxidil? Topical Sodium Valproate

      in Research/Science  52 upvotes 6 months ago
      Topical sodium valproate may promote hair growth by inhibiting GSK3β, allowing beta-catenin to proliferate, but it has potential side effects and requires more research. The conversation also mentions skepticism about a product called Vdphlo1, which includes sodium valproate and other ingredients.

      community The DEFINITIVE cure for hairloss

      in Satire  270 upvotes 2 months ago
      The conversation humorously suggests using immunosuppressants like ciclosporine and oral minoxidil for hair regrowth, with a satirical plan involving hair transplants from family members. It highlights the side effects and impracticality of such treatments, emphasizing the post's satirical nature.

      community Wouldn’t this nuclear stack make it almost impossible to lose hair?

      in Research/Science  65 upvotes 1 month ago
      The conversation discusses a hair loss treatment regimen involving dutasteride, pyrilutamide, oral minoxidil, and microneedling, with the aim of suppressing DHT and stimulating hair growth. Users debate the effectiveness and potential side effects of these treatments, noting that individual results may vary and that no treatment is foolproof.

    Similar Research

    6 / 1000+ results