A Small Molecule Modulator of the Wnt Pathway (SM04554) as a Potential Topical Treatment for Androgenetic Alopecia

April 2017 in “ Journal of Investigative Dermatology ”

V. Deshmukh, M. Pedraza, Charlene F. Barroga, John T. Seykora, Yusuf Yazici

SM04554 Wnt pathway androgenetic alopecia topical treatment follicle numbers hair growth AGA

TLDR SM04554 may increase hair growth as a topical treatment for androgenetic alopecia.

The document discusses the potential use of a small molecule modulator of the Wnt pathway, SM04554, as a topical treatment for androgenetic alopecia (AGA). Preclinical studies on male mice and mini-pigs showed that SM04554 increased follicle numbers and hair growth compared to vehicle, indicating its potential as a topical therapy for AGA. Clinical studies were ongoing at the time of the document's publication.

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The conversation expresses frustration over the lack of progress in hair loss treatments, with specific mentions of Minoxidil, finasteride, and RU58841. Users discuss the slow development of new treatments and the potential of hair transplants.

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The conversation is about individuals considering waiting for Breezula to treat hair loss instead of using Finasteride due to concerns about side effects. Some are opting for Finasteride now, while others are wary of its impact on neurosteroids.

community When will Breezula, SM04554, Follica FOL-004, follicum FOL-005 arrive in Canada?

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The conversation is about the availability of hair loss treatments Breezula, SM04554, Follica FOL-004, and Follicum FOL-005 in Canada after FDA approval, including potential delays, loopholes for obtaining them, and insurance coverage.

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in Question 18 upvotes 5 years ago

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community Sensitive to Oral fin + RU. Am I screwed?

in Product 6 upvotes 3 years ago

Akinfenrawr experienced negative side effects from oral finasteride and RU58841, and is seeking alternative hair loss treatments. They discuss various options, including raloxifene, oral dutasteride, liposomal finasteride, Breezula, Pyrilutamide, SM04554, and sulforaphane, but have concerns about efficacy, availability, and cost.

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First patient dosed with Pyrilutamide (Kintor) Phase III for hair loss treatment. Pyrilutamide differs from approved treatments as it competes with DHT to bind hair follicles, potentially reducing side effects.

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research Small Molecule Wnt Pathway Inhibitor (SM04755) as a Potential Topical Psoriasis Treatment

April 2017 in “Journal of Investigative Dermatology”

SM04755 may be an effective topical treatment for psoriasis.