A Small Molecule Modulator of the Wnt Pathway (SM04554) as a Potential Topical Treatment for Androgenetic Alopecia

April 2017 in “ Journal of Investigative Dermatology ”

V. Deshmukh, M. Pedraza, Charlene F. Barroga, John T. Seykora, Yusuf Yazici

SM04554 Wnt pathway androgenetic alopecia topical treatment follicle numbers hair growth AGA

TLDR SM04554 may increase hair growth as a topical treatment for androgenetic alopecia.

The document discusses the potential use of a small molecule modulator of the Wnt pathway, SM04554, as a topical treatment for androgenetic alopecia (AGA). Preclinical studies on male mice and mini-pigs showed that SM04554 increased follicle numbers and hair growth compared to vehicle, indicating its potential as a topical therapy for AGA. Clinical studies were ongoing at the time of the document's publication.

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in Question 17 upvotes 6 years ago

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community Sensitive to Oral fin + RU. Am I screwed?

in Product 6 upvotes 3 years ago

Akinfenrawr experienced negative side effects from oral finasteride and RU58841, and is seeking alternative hair loss treatments. They discuss various options, including raloxifene, oral dutasteride, liposomal finasteride, Breezula, Pyrilutamide, SM04554, and sulforaphane, but have concerns about efficacy, availability, and cost.

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research Small Molecule Wnt Pathway Inhibitor (SM04755) as a Potential Topical Psoriasis Treatment

April 2017 in “Journal of Investigative Dermatology”

SM04755 may be an effective topical treatment for psoriasis.