A Small Molecule Modulator of the Wnt Pathway (SM04554) as a Potential Topical Treatment for Androgenetic Alopecia

    April 2017 in “ Journal of Investigative Dermatology ”
    V. Deshmukh, M. Pedraza, Charlene F. Barroga, John T. Seykora, Yusuf Yazici
    Image of study
    TLDR SM04554 may increase hair growth as a topical treatment for androgenetic alopecia.
    The document discusses the potential use of a small molecule modulator of the Wnt pathway, SM04554, as a topical treatment for androgenetic alopecia (AGA). Preclinical studies on male mice and mini-pigs showed that SM04554 increased follicle numbers and hair growth compared to vehicle, indicating its potential as a topical therapy for AGA. Clinical studies were ongoing at the time of the document's publication.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 9 results

      community Don’t Get Too Hyped About PP405. We've Seen This Movie Before.

      in Research/Science  203 upvotes 1 week ago
      PP405 is a new hair loss treatment showing early promise with a 20% hair density increase, but skepticism exists due to past failures of similar treatments like Pyrilutamide, RU58841, and Bimatoprost. Users debate its potential effectiveness, with some hopeful due to Google's involvement, while others urge caution without more evidence.

      community Anyone here holding out for Breezula?

      in Treatment  7 upvotes 4 years ago
      The conversation is about individuals considering waiting for Breezula to treat hair loss instead of using Finasteride due to concerns about side effects. Some are opting for Finasteride now, while others are wary of its impact on neurosteroids.

      community Is Breezula The Real Deal?

      in Question  19 upvotes 6 years ago
      The conversation is about the effectiveness of Breezula for hair loss, with skepticism expressed due to lack of scientific proof and mixed results from those using Breezula and RU58841. Some are waiting for clinical trial results before trying treatments like Breezula and SM04554.

      community Sensitive to Oral fin + RU. Am I screwed?

      in Product  6 upvotes 3 years ago
      Akinfenrawr experienced negative side effects from oral finasteride and RU58841, and is seeking alternative hair loss treatments. They discuss various options, including raloxifene, oral dutasteride, liposomal finasteride, Breezula, Pyrilutamide, SM04554, and sulforaphane, but have concerns about efficacy, availability, and cost.

    Related Research

    1 / 1 results