Fisetin Promotes Differentiation, Inhibits Proliferative and Inflammatory Responses in Cultured Human Cells and Alleviates Psoriasiform Dermatitis in Mice

In the 2017 study, fisetin, a flavonoid found in many fruits and vegetables, was shown to have therapeutic effects on psoriasis. Laboratory experiments demonstrated that fisetin reduced cell viability and proliferation in human epidermal keratinocytes, decreased the production of pro-inflammatory mediators, and enhanced cell differentiation. Additionally, when applied topically to mice, fisetin significantly improved symptoms of psoriasis-like skin inflammation, including reducing skin thickness, inhibiting cell proliferation and immune cell infiltration, decreasing angiogenesis, and modulating inflammatory cytokines and chemokines. The study indicates fisetin's potential as a treatment for psoriasis and other inflammatory skin conditions.