SIG-1451: A Topical Anti-Inflammatory New Chemical Entity for Atopic Dermatitis

    April 2017 in “ Journal of Investigative Dermatology ”
    José R. Fernández, Karl Rouzard, Corey Webb, Michael V. Voronkov, Jason Healy, Kristen L. Huber, Jeffry B. Stock, Maxwell Stock, Joel S. Gordon, Eduardo Salcedo Pérez
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    TLDR SIG-1451 could be a promising new treatment for atopic dermatitis.
    The document from May 1, 2017, reports on the effectiveness of SIG-1451, a new non-steroidal anti-inflammatory drug for atopic dermatitis (AD). The study showed that SIG-1451 inhibits pro-inflammatory cytokines such as IL-4 in human PBMCs, IL-6 in endothelial cells, and TSLP in NHEKS induced by S. aureus, which are key in AD pathogenesis. The in vitro potency of SIG-1451 was comparable or superior to existing AD treatments, with the exception of IL-4 induction by AN2728. Additionally, in vivo models demonstrated SIG-1451's anti-inflammatory properties, reducing edema in both the TPA acute inflammation ear model and the oxazolone mouse model for delayed type hypersensitivity (DTH). The study concludes with the potential of SIG-1451 as a drug candidate for AD, with preclinical safety evaluations in progress for an Investigational New Drug (IND) submission.
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