Nitric Oxide-Releasing Topical Therapeutic Agent for Atopic Dermatitis

    April 2017 in “ Journal of Investigative Dermatology ”
    Kimberly McHale, Joel Gil, S C Davis, Stan Hollenbach, Nathan Stasko
    Image of study
    TLDR SB414 may be an effective treatment for atopic dermatitis by reducing swelling and bacterial infection.
    The document reported on the effectiveness of SB414, a nitric oxide-releasing topical agent, in treating atopic dermatitis (AD). In a murine model, SB414 achieved a dose-dependent reduction in ear swelling, with the highest dose (6.0%) significantly reducing swelling by 5%, compared to an 80% reduction with 0.05% betamethasone cream. Additionally, in a porcine skin wound model infected with S. aureus, SB414 significantly reduced bacterial counts in a dose-dependent manner, with the highest dose showing a greater than 3-log reduction after five treatments. These findings indicate that SB414 could be a promising therapy for AD by modulating immune responses and decreasing S. aureus skin colonization.
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