Cell-Free Fat Extract Restores Hair Loss: A Novel Therapeutic Strategy for Androgenetic Alopecia

August 2023 in “ Stem Cell Research & Therapy ”

Yu Cai, Zhuoxuan Jia, Yichen Zhang, Bijun Kang, Chingyu Chen, Wei Liu, Wei Li, Wenjie Zhang

Cell-free fat extract CEFFE androgenetic alopecia AGA dermal papilla cells DPCs dihydrotestosterone DHT androgen receptor AR hair follicle density hair growth rate regional angiogenesis fat extract hair loss hair growth hormone regulation

TLDR A substance called Cell-free fat extract can effectively treat common hair loss by increasing hair growth and density.

The study evaluated the effectiveness of Cell-free fat extract (CEFFE) in treating Androgenetic alopecia (AGA), a common hair loss disease. The research involved five groups of male C57BL/6 mice (n=12 in each group) treated with different concentrations of CEFFE for 18 days. The results showed that CEFFE-treated mice had an increased hair growth rate and hair coverage percentage. CEFFE also promoted the proliferation of dermal papilla cells (DPCs), modulated the cell cycle arrest, inhibited apoptosis caused by dihydrotestosterone (DHT), reduced the intracellular concentration of DHT in DPCs, and downregulated the expression of androgen receptor (AR). The study concluded that CEFFE is a novel and effective treatment for AGA, increasing hair follicle density and hair growth rate through the DHT/AR pathway regulation and regional angiogenesis ability.

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