Regulation of the Wound Healing Response During Aging

    February 2021 in “ Journal of Investigative Dermatology ”
    Xiaolei Ding, Parisa Kakanj, Maria Leptin, Sabine A. Eming
    Studysummary This review examines the complexities of age-related skin healing and discusses how translating findings from model organisms to humans could enhance understanding and treatment of impaired regeneration in aging populations, but it reports no new clinical results.
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    Research cited in this study 13

    1. Dermal Adipocyte Lipolysis and Myofibroblast Conversion Are Required for Efficient Skin Repair Cell Stem Cell · 2020
    2. Scars Or Regeneration? Dermal Fibroblasts As Drivers Of Diverse Skin Wound Responses International Journal of Molecular Sciences · 2020
    3. Dermal Adipose Tissue Has High Plasticity And Undergoes Reversible Dedifferentiation In Mice Journal of Clinical Investigation · 2019
    4. Choreographing Immunity in the Skin Epithelial Barrier Immunity · 2019
    5. Age-Related Loss of Innate Immune Antimicrobial Function of Dermal Fat Is Mediated by Transforming Growth Factor Beta Immunity · 2018
    6. Stem Cell Dynamics, Migration, and Plasticity During Wound Healing Nature Cell Biology · 2018
    7. Wound Healing: A Cellular Perspective Physiological Reviews · 2018
    8. Diverse Mechanisms for Endogenous Regeneration and Repair in Mammalian Organs Nature · 2018
    9. Defining Stem Cell Dynamics and Migration During Wound Healing in Mouse Skin Epidermis Nature Communications · 2017
    10. Distinct Fibroblast Lineages Determine Dermal Architecture in Skin Development and Repair Nature · 2013
    11. Age-Associated Inflammation Inhibits Epidermal Stem Cell Function Genes & development · 2012
    12. Wnt Signaling and Injury Repair Cold Spring Harbor Perspectives in Biology · 2012
    13. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007