Regulation of the Wound Healing Response During Aging

    February 2021 in “ Journal of Investigative Dermatology ”
    Xiaolei Ding, Parisa Kakanj, Maria Leptin, Sabine A. Eming
    Studysummary This review examines the complexities of age-related skin healing and discusses how translating findings from model organisms to humans could enhance understanding and treatment of impaired regeneration in aging populations, but it reports no new clinical results.
    Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
    The document reviewed how aging impairs wound healing due to factors like cellular senescence, reduced immune response, and altered signaling pathways. It highlighted structural changes in aged skin, such as reduced fibroblast density and increased collagen fragmentation, leading to delayed wound closure and impaired tissue repair. Aged macrophages and neutrophils exhibited diminished functionality, contributing to slower healing. The study suggested that targeting senescent cells and metabolic pathways could improve healing outcomes. Techniques like single-cell sequencing and CRISPR/cas9 were emphasized for advancing the understanding of age-dependent changes in wound healing.
    Discuss this study in the Community →

    Research cited in this study

    13 / 13 results