Spatio-Temporal Regulation of Gene Expression Defines Subpopulations of Epidermal Stem Cells

The document discusses the progress in identifying and characterizing epidermal stem cells, which are important for their regenerative capabilities in therapies. It highlights the use of single-cell transcriptomics to reveal the heterogeneity among these cells and the challenges in separating stem cells from their differentiated progeny. The study also mentions the use of advanced techniques like pseudotime inference, RNA velocity, and cellular entropy to better understand the plasticity of epidermal stem cells. This plasticity refers to the cells' ability to change and adapt, which has significant implications for regenerative medicine. The main findings of the research emphasize the discovery of this plastic trait and its potential applications.