Curcumin And Cancer Biology: Focusing Regulatory Effects In Different Signalling Pathways

    April 2021 in “ Phytotherapy Research ”
    Muskan Bhatia, Mihir Bhalerao, Natália Martins, Dileep Kumar
    TLDR Curcumin may be an effective and safer anticancer agent by regulating key cell pathways.
    The review focused on the potential of curcumin, a phytochemical from Curcuma longa L., as an anticancer agent with minimal side effects compared to traditional treatments like chemotherapy and radiation. Curcumin was found to influence cancer development by regulating multiple microRNA expressions and modifying various signaling pathways, including Akt, Bcl-2, PTEN, p53, Notch, and Erbb. It also targeted matrix metalloproteinase (MMP) gene expression, which is crucial in cell-extracellular matrix degradation, a process involved in cancer progression. The review highlighted curcumin's regulatory effects on pathways such as JAK/STAT, NF-κB, MAPK/ERK, COX-2, ROS, and TGF-β, emphasizing its therapeutic potential in cancer treatment.
    Discuss this study in the Community →