Curcumin And Cancer Biology: Focusing Regulatory Effects In Different Signalling Pathways

    April 2021 in “ Phytotherapy Research ”
    Muskan Bhatia, Mihir Bhalerao, Natália Martins, Dileep Kumar
    TLDR Curcumin may be an effective and safer anticancer agent by regulating key cell pathways.
    Curcumin, a bright yellow substance from Curcuma longa L., was highlighted for its potential in cancer therapy due to its ability to regulate multiple microRNA expressions and modify various signalling pathways, including Akt, Bcl-2, PTEN, p53, Notch, Erbb, and MMP gene expression. These pathways are crucial in cancer progression, and curcumin's regulatory effects on them suggested it could be an effective anticancer agent with fewer side effects compared to traditional treatments like chemotherapy, surgery, and radiation therapy. The review focused on curcumin's impact on cell signalling pathways involved in different types of cancers.
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