Clinical Exome Sequencing Unveils the Genetic Landscape of Polycystic Ovarian Syndrome Focusing on Lean and Obese Phenotypes: Implications for Cost-Effective Diagnosis and Personalized Treatment

    Shrinjana Dhar, Pritha Bhattacharjee

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary This study found that among young women in West Bengal, India, co-occurring PCOS and related conditions like estrogen resistance and leptin receptor insufficiency are common, with notable genetic variations identified, including impairments in leptin signaling and insulin resistance.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 3

    1. High-Throughput Sequencing to Identify Monogenic Etiologies in a Preselected Polycystic Ovary Syndrome Cohort Journal of the Endocrine Society · 2022
    2. The Androgen Excess and PCOS Society Criteria for the Polycystic Ovary Syndrome: The Complete Task Force Report Fertility and Sterility · 2008
    3. Polycystic Ovary Syndrome: Early Detection in Adolescents Clinical obstetrics and gynecology · 2007

    Related research 4

    1. Current Aspects of Polycystic Ovary Syndrome: A Literature Review Revista Da Associacao Medica Brasileira · 2016
    2. Polycystic Ovary Syndrome and Acne Skin therapy letter · 2011
    3. The Diagnosis of Polycystic Ovary Syndrome in Adolescents American Journal of Obstetrics and Gynecology · 2010
    4. Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome Fertility and Sterility · 2004