First-In-Man Clinical Trial of the Oral Pan-AKT Inhibitor MK-2206 in Patients With Advanced Solid Tumors

    December 2011 in “ Journal of clinical oncology
    Timothy A. Yap, Yan Li, Amita Patnaik, Ivy Fearen, David Olmos, Kyriakos P. Papadopoulos, Richard D. Baird, Liliana Delgado, Akosha Taylor, Lisa C. Lupinacci, Ruth Riisnaes, Lorna Pope, Simon P. Heaton, George V. Thomas, Michelle D. Garrett, Daniel M. Sullivan, Johann S. de Bono, Anthony W. Tolcher
    TLDR MK-2206 was safe and effectively blocked AKT signaling in cancer patients, warranting more trials.
    The first-in-man clinical trial of the oral pan-AKT inhibitor MK-2206 in 33 patients with advanced solid tumors established the maximum-tolerated dose at 60 mg due to dose-limiting toxicities like skin rash and stomatitis. MK-2206 was generally well-tolerated and showed evidence of AKT signaling blockade, with significant declines in phosphorylated AKT in tumor biopsies and suppression in hair follicles. Preliminary antitumor efficacy was observed, including a notable case of a patient with pancreatic adenocarcinoma showing a 60% decrease in cancer antigen 19-9 levels and 23% tumor shrinkage. The results supported further rational combination trials to enhance clinical benefits.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 33 results

      community What is the options after unsuccessful dut+minox 2x a day?

      in Chat  6 upvotes 5 months ago
      The user has been experiencing aggressive hair loss despite using finasteride, minoxidil, dutasteride, ketoconazole, and derma rolling. Suggestions include continuing current treatments, considering RU58841, checking for deficiencies, and possibly trying collagen supplements or oral minoxidil.

      community First time visiting a dermatologist for hairloss, I'm skeptical

      in Chat  12 upvotes 3 years ago
      A user visited a dermatologist for hair loss and was prescribed Minoxidil without a physical examination, leading to skepticism about the thoroughness of the appointment. The user is considering seeking a second opinion due to the lack of tests or physical checks.

      community Breezula CB-03-01

      in Treatment  11 upvotes 5 years ago
      The conversation is about a potential new hair loss treatment called Breezula CB-03-01. Users are discussing updates on its development and sharing personal experiences with making or using it.

      community What do you think about this study?

      in Product  108 upvotes 1 week ago
      The conversation discusses skepticism about new hair loss treatments, with many users expressing doubt about the effectiveness and availability of future solutions. Current treatments like minoxidil, finasteride, and hair transplants are mentioned as reliable options.

    Similar Research

    5 / 1000+ results