Life Sciences Discovery And Technology Highlights
March 2019
in “
SLAS TECHNOLOGY
”
TLDR New technologies show promise in healing wounds, treating cancer, autoimmune diseases, and genetic disorders.
The document discussed innovative approaches in wound healing, cancer treatment, and gene-editing techniques, highlighting the potential of nanotechnology and cellular reprogramming. In wound healing, ceria nanocrystals on mesoporous silica nanoparticles and nanoformulated curcumin in gelatin nanofibers showed promise in rat models by reducing inflammation and promoting skin regeneration. In cancer treatment, DNA nanocarriers and PEGylated PLGA nanoparticles demonstrated effective tumor targeting and reduction in size, while PTEN mRNA-loaded nanoparticles and neutrophil membrane-coated nanoparticles showed potential in prostate cancer and rheumatoid arthritis models, respectively. Gene-editing advancements included CRISPR-Gold for correcting the dystrophin gene in a Duchenne muscular dystrophy mouse model and GNOME laserporation for efficient CRISPR/Cas9 delivery. These studies underscored the potential of these technologies in advancing medical treatments for complex diseases.
